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A brief overview on mechanosensing and stick-slip motion at the leading edge of migrating cells

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Abstract

Cell migration is a highly dynamic and complex process that is crucial for executing many cellular behaviors and functions such as wound healing, morphogenesis, embryonic development, and tissue regeneration, to name a few. Here we provide a brief overview of the theoretical models focussing on the leading edge dynamics during the migration of cells. Besides, we also highlight the role of substrate mechanical properties, namely substrate elasticity and viscosity, in determining the cellular response in migration and spreading. In addition, we briefly discuss our theoretical model that elucidates the emergence of stick-slip motion during the crawling of cells on viscoelastic substrates. We further compare how the stick-slip dynamics are influenced by the force-dependent nature of the adhesion bonds dissociation pathways displaying catch versus slip behaviors.

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Acknowledgements

The authors acknowledge the financial support from Science and Engineering Research Board (SERB), Grant No. SR/FTP/PS-105/2013, Department of Science and Technology (DST), India.

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  1. Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, West Bengal, India

    Rumi De & Partho Sakha De

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  1. Rumi De
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  2. Partho Sakha De
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Correspondence to Rumi De or Partho Sakha De.

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De, R., De, P.S. A brief overview on mechanosensing and stick-slip motion at the leading edge of migrating cells. Indian J Phys 96, 2629–2638 (2022). https://doi.org/10.1007/s12648-022-02297-0

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