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Rationale for cross-species infection and cross-subtype mutation in hemagglutinins from influenza A virus

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Abstract

The current H1N1 swine pandemic raises the question why the cross-species infection and cross-subtype mutation are so easy. In this study, we use ANOVA to analyze all influenza A virus hemagglutinins available in database in order to answer this question. The results show that there are differences between species and between subtypes in most cases, but the intra-subtype/species variation is generally larger than the inter-subtype/species variation, which provides the rational for cross-species infection and cross-subtype mutation.

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Authors and Affiliations

  1. National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, P.R. China

    Shao-Min Yan

  2. Computational Mutation Project, DreamSciTech Consulting, Shenzhen, Guangdong, 518054, P.R. China

    Guang Wu

Authors
  1. Shao-Min Yan
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  2. Guang Wu
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Correspondence to Guang Wu.

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Yan, SM., Wu, G. Rationale for cross-species infection and cross-subtype mutation in hemagglutinins from influenza A virus. Interdiscip Sci Comput Life Sci 1, 303–307 (2009). https://doi.org/10.1007/s12539-009-0068-1

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  • DOI: https://doi.org/10.1007/s12539-009-0068-1

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