Abstract
Primary myelofibrosis (PMF) is a rare hematological disorder associated with progressive cytopenia and extra-medullary hematopoiesis. Acute kidney injury in this disease has been reported from diverse etiologies such as renal and peri-renal extramedullary hematopoiesis and tumor lysis syndrome. We report a patient who presented with obstructive uropathy from uric acid stones who was incidentally diagnosed with PMF during workup for persistent thrombocytosis and leukocytosis. Marrow histopathology was unique in presenting features of early PMF despite clinical picture mimicking essential thrombocythemia. Despite a common background of hyperuricemia in myeloproliferative neoplasms, AKI resulting from urate nephrolithiasis has seldom been reported in PMF. Published data on this association and clinical management is reviewed briefly.
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Anirban Ganguli, Ramandeep Singh Chalokia and Brahm Jyot Kaur declare that they have no conflict of interest related in any way to the design, conduct or publication of this manuscript.
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This article is a retrospective case review and does not involve any experimentation on animals or human participants.
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Informed consent was obtained from patient for publishing this case report (also mentioned in manuscript).
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Ganguli, A., Chalokia, R.S. & Kaur, B.J. Obstructive Uropathy as an Initial Presentation of Primary Myelofibrosis: Case Report and Review of Literature. Indian J Hematol Blood Transfus 32 (Suppl 1), 117–120 (2016). https://doi.org/10.1007/s12288-016-0679-6
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DOI: https://doi.org/10.1007/s12288-016-0679-6