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Correlation Between CCG Polymorphisms and CAG Repeats During Germline Transmission in Chinese Patients with Huntington’s Disease

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References

  1. MacDonald ME, Ambrose CM, Duyao MP, Myers RH, Lin C, Srinidhi L, et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. The Huntington’s Disease Collaborative Research Group. Cell 1993, 72: 971–983.

    Article  Google Scholar 

  2. Squitieri F, Andrew SE, Goldberg YP, Kremer B, Spence N, Zeisler J, et al. DNA haplotype analysis of Huntington disease reveals clues to the origins and mechanisms of CAG expansion and reasons for geographic variations of prevalence. Hum Mol Genet 1994, 3: 2103–2114.

    Article  CAS  Google Scholar 

  3. Li XY, Zhang YB, Xu M, Cheng HR, Dong Y, Ni W, et al. Effect of apolipoprotein E genotypes on Huntington’s disease phenotypes in a Han Chinese population. Neurosci Bull 2019, 35: 756–762.

    Article  CAS  Google Scholar 

  4. Li HL, Li XY, Zhang YB, Dong Y, Cheng HR, Gan SR, et al. Clinical and genetic profiles in Chinese patients with Huntington’s disease: A ten-year multicenter study in China. Aging Dis 2019, 10:1003–1011.

    Article  Google Scholar 

  5. Kremer B, Almqvist E, Theilmann J, Spence N, Telenius H, Goldberg YP, et al. Sex-dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes. Am J Hum Genet 1995, 57: 343–350.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Li XY, Li HL, Dong Y, Gao B, Cheng HR, Ni W, et al. Haplotype analysis encompassing HTT gene in Chinese patients with Huntington’s disease. Eur J Neurol 2020, 27: 273–279.

    Article  Google Scholar 

  7. Kay C, Collins J, Skotte JH, Southwell AL, Warby SC, Caron NS, et al. Huntingtin Haplotypes provide prioritized target panels for allele-spectic silencing in Huntington disease of European ancestry. Mol Ther 2015, 11: 1759–1771.

    Article  Google Scholar 

  8. Warby SC, Montpetit A, Hayden AR, Carroll JB, Butland SL, Visscher H, et al. CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup. Am J Hum Genet 2009, 84: 351–366.

    Article  CAS  Google Scholar 

  9. Hecimovic S, Klepac N, Vlasic J, Vojta A, Janko D, Skarpa-Prpic I, et al. Genetic background of Huntington disease in Croatia: Molecular analysis of CAG, CCG, and Delta2642 (E2642del) polymorphisms. Hum Mutat 2002, 20: 233.

    Article  Google Scholar 

  10. Morovvati S, Nakagawa M, Osame M, Karami A. Analysis of CCG repeats in Huntingtin gene among HD patients and normal populations in Japan. Arch Med Res 2008, 39: 131–133.

    Article  CAS  Google Scholar 

  11. Ma M, Yang Y, Shang H, Su D, Zhang H, Ma Y, et al. Evidence for a predisposing background for CAG expansion leading to HTT mutation in a Chinese population. J Neurol Sci 2010, 298: 57–60.

    Article  CAS  Google Scholar 

  12. Zhang BR, Tian J, Yan YP, Yin XZ, Zhao GH, Wu ZY, et al. CCG polymorphisms in the huntingtin gene have no effect on the pathogenesis of patients with Huntington’s disease in mainland Chinese families. J Neurol Sci 2012, 312: 92–96.

    Article  CAS  Google Scholar 

  13. Dong Y, Sun YM, Liu ZJ, Ni W, Shi SS, Wu ZY. Chinese patients with Huntington’s disease initially presenting with spinocerebellar ataxia. Clin Genet 2013, 83: 380–383.

    Article  CAS  Google Scholar 

  14. Masuda N, Goto J, Murayama N, Watanabe M, Kondo I, Kanazawa I, et al. Analysis of triplet repeats in the huntingtin gene in Japanese families affected with Huntington’s disease. J Med Genet 1995, 32: 701–705.

    Article  CAS  Google Scholar 

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Acknowledgements

We sincerely thank the participants for their help and willingness to take part in this study. We especially thank Wan-Qing Xu for help with grammar and expression. This work was supported by the Key Research and Development Project of Zhejiang Province, China (2019C03039), and the Research Foundation for Distinguished Scholars of Zhejiang University, China (188020-193810101/089).

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Author notes

  1. Hong-Rong Cheng and Xiao-Yan Li have contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology and Research Center of Neurology in the Second Affiliated Hospital, and Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, 310009, China

    Hong-Rong Cheng, Xiao-Yan Li, Hui-Li Yu, Hong-Lei Li & Zhi-Ying Wu

  2. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China

    Miao Xu

  3. Department of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China

    Yan-Bin Zhang & Shi-Rui Gan

  4. Joint Institute for Genetics and Genome Medicine between Zhejiang University and the University of Toronto, Zhejiang University, Hangzhou, 310058, China

    Zhi-Ying Wu

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  1. Hong-Rong Cheng
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  2. Xiao-Yan Li
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Correspondence to Hong-Lei Li or Zhi-Ying Wu.

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Cheng, HR., Li, XY., Yu, HL. et al. Correlation Between CCG Polymorphisms and CAG Repeats During Germline Transmission in Chinese Patients with Huntington’s Disease. Neurosci. Bull. 36, 811–814 (2020). https://doi.org/10.1007/s12264-020-00485-8

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  • DOI: https://doi.org/10.1007/s12264-020-00485-8

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