Skip to main content

Advertisement

Log in

Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis

  • Original Article
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

Studies examining risk factors associated with vasovagal reactions (VVRs) during autologous blood donations, especially in younger subjects, have been limited. The aim of the present study was to define risk factors for VVRs during preoperative autologous blood donation in patients, including those younger than 18 years old. We retrospectively analyzed 4192 autologous, preoperative blood donations between 2007 and 2015 at Okayama University Hospital. Eighty-seven (2.08%) of the patients experienced VVRs. VVRs occurred approximately three times as often in patients 0–17 years old (16/320, 5.0%) than in patients 18 years and older (71/3872, 1.8%). In particular, VVRs occurred more frequently in those 10–13 years old, and decreased with older age (P = 0.006). In a univariate analysis, younger age, lower body mass index, lower systolic blood pressure, lower body weight, lower total blood volume, female gender, first-time collection, and higher heart rate were associated with a higher incidence of VVRs. In a multivariate analysis, lower systolic blood pressure (P < 0.001), higher heart rate (P = 0.007), and first-time collection (P = 0.015), remained independent predictors of VVRs. These results emphasize the need for careful attention during blood collection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Gandini G, Franchini M, de Gironcoli M, Giuffrida A, Bertuzzo D, Zanolla L, et al. Preoperative autologous blood donation by elderly patients undergoing orthopaedic surgery. Vox Sang. 2001;80:95–100.

    Article  CAS  PubMed  Google Scholar 

  2. Trouern-Trend JJ, Cable RG, Badon SJ, Newman BH, Popovsky MA. A case-controlled multicenter study of vasovagal reactions in blood donors: influence of sex, age, donation status, weight, blood pressure, and pulse. Transfusion. 1999;39:316–20.

    Article  CAS  PubMed  Google Scholar 

  3. Tomita T, Takayanagi M, Kiwada K, Mieda A, Takahashi C, Hata T. Vasovagal reactions in apheresis donors. Transfusion. 2002;42:1561–6.

    Article  PubMed  Google Scholar 

  4. Kasprisin DO, Glynn SH, Taylor F, Miller KA. Moderate and severe reactions in blood donors. Transfusion. 1992;32:23–6.

    Article  CAS  PubMed  Google Scholar 

  5. Aydin MA, Salukhe TV, Wilke I, Willems S. Management and therapy of vasovagal syncope: a review. World J Cardiol. 2010;2:308–15.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Tomasulo PA, Anderson AJ, Paluso MB, Gutschenritter MA, Aster RH. A study of criteria for blood donor deferral. Transfusion. 1980;20:511–8.

    Article  CAS  PubMed  Google Scholar 

  7. Graham DT. Prediction of fainting in blood donors. Circulation. 1961;23:901–6.

    Article  CAS  PubMed  Google Scholar 

  8. Nakane T, Nakamae H, Koh H, Nakamae M, Aimoto R, Terada Y, et al. Heart rate variability during and after peripheral blood stem cell leukapheresis in autologous transplant patients and allogeneic transplant donors. Int J Hematol. 2010;91:478–84.

    Article  PubMed  Google Scholar 

  9. Nadler SB, Hidalgo JH, Bloch T. Prediction of blood volume in normal human adults. Surgery. 1962;51:224–32.

    PubMed  Google Scholar 

  10. Crocco I, Franchini M, Garozzo G, Gandini AR, Gandini G, Bonomo P, et al. Adverse reactions in blood and apheresis donors: experience from two Italian transfusion centres. Blood Transfus. 2009;7:35–8.

    PubMed  PubMed Central  Google Scholar 

  11. McVay PA, Andrews A, Kaplan EB, Black DB, Stehling LC, Strauss RG, et al. Donation reactions among autologous donors. Transfusion. 1990;30:249–52.

    Article  CAS  PubMed  Google Scholar 

  12. Kasper SM, Weimbs G, Sabatowski R, Wassmer G. A randomized crossover trial of IV fluid replacement versus no fluid replacement in autologous blood donors with cardiovascular disease. Transfusion. 2002;42:226–31.

    Article  PubMed  Google Scholar 

  13. Masuda M, Kawachi Y, Inaba S, Matsuzaki K, Fukumura F, Morita S, et al. Preoperative autologous blood donations in pediatric cardiac surgery. Ann Thorac Surg. 1995;60:1694–7.

    Article  CAS  PubMed  Google Scholar 

  14. Popovsky MA, Whitaker B, Arnold NL. Severe outcomes of allogeneic and autologous blood donation: frequency and characterization. Transfusion. 1995;35:734–7.

    Article  CAS  PubMed  Google Scholar 

  15. AuBuchon JP, Popovsky MA. The safety of preoperative autologous blood donation in the nonhospital setting. Transfusion. 1991;31:513–7.

    Article  CAS  PubMed  Google Scholar 

  16. Owings DV, Kruskall MS, Thurer RL, Donovan LM. Autologous blood donations prior to elective cardiac surgery. Safety and effect on subsequent blood use. JAMA. 1989;262:1963–8.

    Article  CAS  PubMed  Google Scholar 

  17. Newman BH. Vasovagal reactions in high school students: findings relative to race, risk factor synergism, female sex, and non-high school participants. Transfusion. 2002;42:1557–60.

    Article  CAS  PubMed  Google Scholar 

  18. Eder AF, Hillyer CD, Dy BA. Notari EPt, Benjamin RJ. Adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds. JAMA. 2008;299:2279–86.

    Article  CAS  PubMed  Google Scholar 

  19. Laitinen T, Hartikainen J, Vanninen E, Niskanen L, Geelen G, Lansimies E. Age and gender dependency of baroreflex sensitivity in healthy subjects. J Appl Physiol. 1998;84:576–83.

    CAS  PubMed  Google Scholar 

  20. Gribbin B, Pickering TG, Sleight P, Peto R. Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res. 1971;29:424–31.

    Article  CAS  PubMed  Google Scholar 

  21. Moya A, Sutton R, Ammirati F, Blanc JJ, Brignole M, Dahm JB, et al. Guidelines for the diagnosis and management of syncope (version 2009). Eur Heart J. 2009;30:2631–71.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Steptoe A, Sawada Y. Assessment of baroreceptor reflex function during mental stress and relaxation. Psychophysiology. 1989;26:140–7.

    Article  CAS  PubMed  Google Scholar 

  23. Ogata H, Iinuma N, Nagashima K, Akabane T. Vasovagal reactions in blood donors. Transfusion. 1980;20:679–83.

    Article  CAS  PubMed  Google Scholar 

  24. Takanashi M, Odajima T, Aota S, Sudoh M, Yamaga Y, Ono Y, et al. Risk factor analysis of vasovagal reaction from blood donation. Transfus Apher Sci. 2012;47:319–25.

    Article  PubMed  Google Scholar 

  25. Newman BH. Management of young blood donors. Transfus Med Hemother. 2014;41:284–95.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Eder AF, Dy BA, Kennedy JM, Notari Iv EP, Strupp A, Wissel ME, et al. The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006. Transfusion. 2008;48:1809–19.

    Article  PubMed  Google Scholar 

  27. Wiltbank TB, Giordano GF, Kamel H, Tomasulo P, Custer B. Faint and prefaint reactions in whole-blood donors: an analysis of predonation measurements and their predictive value. Transfusion. 2008;48:1799–808.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Noboru Asada, Hideaki Fujiwara, Yujin Kobayashi, Yusuke Meguri, Tatsunori Ishikawa, Takanori Yoshioka, Mariko Endo, and Takako Kumamoto for their skillful management.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hisakazu Nishimori.

Ethics declarations

Conflict of interest

The authors have no potential conflict of interest to report related to this article.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nishimori, H., Fujii, N., Fujii, K. et al. Predictors of vasovagal reactions during preoperative autologous blood donation: a single-institution analysis. Int J Hematol 105, 812–818 (2017). https://doi.org/10.1007/s12185-017-2204-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12185-017-2204-6

Keywords

Navigation