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Cytogenetics and clinical features of pediatric myelodysplastic syndrome in Japan

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An Erratum to this article was published on 16 July 2015

Abstract

We analyzed the cytogenetics and clinical features of pediatric myelodysplastic syndrome (MDS) in Japan. Data on patients (<16 years) diagnosed with MDS from 1990 to 2000 were retrospectively collected from pediatric hematologists in 234 institutions. Chromosome analysis was successfully performed in 255 of 277 MDS patients. The numbers of patients with refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess of blasts (RAEB), refractory anemia with excess of blasts in transformation (RAEBt), chronic myelomonocytic leukemia, and juvenile myelomonocytic leukemia were 67 (24 %), 51 (18 %), 51 (18 %), 20 (7 %), and 65 (23 %), respectively. The other 23 patients (8 %) could not be classified specifically. The distribution of childhood MDS in Japan according to the French–American–British subclassification was similar to that in other countries. However, we identified a higher incidence of therapy-related cases. As for relationship between cytogenetics and prognoses, abnormal karyotypes were related to poorer prognoses than normal karyotype (P < 0.01). However, patients with trisomy 8 had prognoses comparable to those with normal karyotypes. Complex karyotypes were associated with poorer prognoses among RAEB and RAEBt patients. In conclusion, prognosis of pediatric MDS is related to cytogenetics. A more precise diagnosis and classification system is needed for childhood MDS.

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Acknowledgments

We thank all the members of the Japanese Society of Pediatric Hematology-Oncology.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Saitama, Japan

    Koichi Moriwaki

  2. Department of Pediatrics, St. Luke’s International Hospital, Tokyo, Japan

    Atsushi Manabe

  3. Division of Blood Transfusion, Shimane University Hospital, Izumo, Japan

    Takeshi Taketani

  4. Department of Pediatrics, Teikyo University, Tokyo, Japan

    Akira Kikuchi

  5. Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

    Tatsutoshi Nakahata

  6. Department of Hematology-Oncology, Gunma Children’s Medical Center, Shibukawa, Gunma, Japan

    Yasuhide Hayashi

Authors
  1. Koichi Moriwaki
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  2. Atsushi Manabe
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  3. Takeshi Taketani
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  4. Akira Kikuchi
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  5. Tatsutoshi Nakahata
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  6. Yasuhide Hayashi
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Corresponding author

Correspondence to Yasuhide Hayashi.

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For the MDS Committee of the Japan Pediatric Hematology Society.

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Moriwaki, K., Manabe, A., Taketani, T. et al. Cytogenetics and clinical features of pediatric myelodysplastic syndrome in Japan. Int J Hematol 100, 478–484 (2014). https://doi.org/10.1007/s12185-014-1674-z

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  • DOI: https://doi.org/10.1007/s12185-014-1674-z

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