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Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation

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Abstract

Isolated primary granulocytic sarcoma is a rare disease that presents as an extramedullary tumor of myeloid lineage cells. Most patients subsequently develop acute myelogenous leukemia (AML) within a short period, and their prognosis is poor. Herein, we report the case of a 33-year-old woman with a primary isolated granulocytic sarcoma which originated in the small intestine. After she recovered from surgery, she received intensive chemotherapy equivalent to that for AML, followed by allogeneic bone marrow transplantation from an HLA-matched, unrelated donor. Four years after the transplantation, she remains in complete remission without graft-versus-host disease or any other symptoms. This case illustrates the effectiveness of our therapeutic strategy for isolated granulocytic sarcoma, not only with surgical resection of the tumor and intensive chemotherapy equivalent to that for AML, but also with allogeneic bone marrow transplantation, performed while no sign of AML is observed.

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Authors and Affiliations

  1. Department of Hematology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Yukiko Kitagawa, Yuichi Sameshima, Hiroko Shiozaki, Masanao Teramura, Michihiko Masuda & Toshiko Motoji

  2. Second Department of Surgery, Tokyo Women’s Medical University, Tokyo, Japan

    Shinpei Ogawa & Shingo Kameoka

  3. Department of Surgical Pathology, Tokyo Women’s Medical University, Tokyo, Japan

    Akihiro Masuda

  4. Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan

    Shin-ichiro Mori

Authors
  1. Yukiko Kitagawa
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  2. Yuichi Sameshima
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  3. Hiroko Shiozaki
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  4. Shinpei Ogawa
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  5. Akihiro Masuda
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  6. Shin-ichiro Mori
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  7. Masanao Teramura
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  8. Michihiko Masuda
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  9. Shingo Kameoka
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  10. Toshiko Motoji
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Corresponding author

Correspondence to Toshiko Motoji.

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Kitagawa, Y., Sameshima, Y., Shiozaki, H. et al. Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation. Int J Hematol 87, 410–413 (2008). https://doi.org/10.1007/s12185-008-0067-6

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  • DOI: https://doi.org/10.1007/s12185-008-0067-6

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