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HCV non-structural protein 3 and HCV RNA genome in non-Hodgkin lymphoma and transition of the serum HCV RNA level: a retrospective analysis in one institution

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Abstract

There have been various reports on the association of hepatitis C virus (HCV) infection with B lymphocyte proliferative disorders, such as non-Hodgkin lymphoma (NHL). We experienced a case (Case 1) of anti-HCV antibody (HCV-Ab)-positive NHL in which HCV nonstructural protein 3 (NS3) expression was observed in lymphoma tissue at the time of recurrence and in which the serum HCV RNA level exhibited a transient increase prior to recurrence. We investigated the HCV RNA genome in lymphoma tissue in Case 1, and it could be detected at recurrence. We also investigated HCV NS3 protein expression in lymphoma tissue and changes in serum HCV RNA level during the clinical course in four other cases of HCV-Ab-positive NHL treated in our hospital. We examined lymphoma tissues for HCV NS3 protein expression in four of the five cases, but it was not identified except for in Case 1 at recurrence. In three cases with no recurrence, serum HCV RNA levels showed a tendency to decrease after completion of chemotherapy and became stable thereafter. Further studies are necessary to clarify the association between serum HCV RNA and the onset and exacerbation of NHL.

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References

  1. Turner NC, Dusheiko G, Jones A, et al. Hepatitis C and B-cell lymphoma. Ann Oncol. 2003;14:1341–5.

    Article  PubMed  CAS  Google Scholar 

  2. Weng WK, Levy S. Hepatitis C virus (HCV) and lymphomagenesis. Leuk Lymphoma. 2003;44(7):1113–20.

    Article  PubMed  CAS  Google Scholar 

  3. Takeuchi T, Katsume A, Tanaka T, et al. Real-time detection system for quantification of hepatitis C virus genome. Gastroenterology. 1999;116(3):636–42.

    Article  PubMed  CAS  Google Scholar 

  4. Vallisa D, Bertè R, Rocca A, et al. Association between hepatitis C virus and non-Hodgkin’s lymphoma, and effects of viral infection on histologic subtype and clinical course. Am J Med. 1999;106(5):556–60.

    Article  PubMed  CAS  Google Scholar 

  5. Talamini R, Montella M, Crovatto M, et al. Non-Hodgkin’s lymphoma and hepatitis C virus: a case–control study from northern and southern Italy. Int J Cancer. 2004;110(3):380–5.

    Article  PubMed  CAS  Google Scholar 

  6. Engels EA, Chatterjee N, Cerhan JR, et al. Hepatitis C virus infection and non-Hodgkin lymphoma: results of the NCI-SEER multi-center case–control study. Int J Cancer. 2004;111(1):76–80.

    Article  PubMed  CAS  Google Scholar 

  7. De Sanjose S, Nieters A, Goedert JJ, et al. Role of hepatitis C virus infection in malignant lymphoma in Spain. Int J Cancer. 2004;111(1):81–5.

    Article  PubMed  Google Scholar 

  8. Takeshita M, Sakai H, Okamura S, et al. Prevalence of hepatitis C virus infection in cases of B-cell lymphoma in Japan. Histopathology. 2006;48:189–98.

    Article  PubMed  CAS  Google Scholar 

  9. Pioltelli P, Gargantini L, Cassi E et al. Hepatitis C virus in non-Hodgkin’s lymphoma. A reappraisal after a prospective case–control study of 300 patients. Am J Hematol. 2000;64(2):95–100.

    Article  PubMed  CAS  Google Scholar 

  10. Hausfater P, Cacoub P, Sterkers Y, et al. Hepatitis C virus infection and lymphoproliferative diseases: prospective study on 1,576 patients in France. Am J Hematol. 2001;67(3):168–71.

    Article  PubMed  CAS  Google Scholar 

  11. Avilès A, Valdez L, Halabe J, et al. No association between lymphoma and hepatitis C virus. Med Oncol. 2003;20(2):165–8.

    Article  PubMed  Google Scholar 

  12. Mele A, Pulsoni A, Bianco E, et al. Hepatitis C virus and B-cell non-Hodgkin’s lymphomas: an Italian multicenter case–control study. Blood. 2003;102(3):996–9.

    Article  PubMed  CAS  Google Scholar 

  13. Rosa D, Saletti G, De Gregorio E, et al. Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders. Proc Natl Acad Sci USA. 2005;102(51):18544–9.

    Article  PubMed  CAS  Google Scholar 

  14. Quinn ER, Chan CH, Hadlock KG, et al. The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis. Blood. 2001;98(13):3745–9.

    Article  PubMed  CAS  Google Scholar 

  15. Takeshita M, Sakai H, Okamura S, et al. Splenic large B-cell lymphoma in patients with hepatitis C virus infection. Hum Pathol. 2005;36:878–85.

    Article  PubMed  CAS  Google Scholar 

  16. Paydas S, Ergin M, Tanriverdi K, et al. Detection of hepatitis C virus RNA in paraffin-embedded tissues from patients with non-Hodgkin’s lymphoma. Am J Hematol. 2004;76:252–7.

    Article  PubMed  CAS  Google Scholar 

  17. Sebastian J K, Gururaj K, Huifeng-Jenny L, et al. Detection of hepatitis C virus RNA sequences in B-cell non-Hodgkin lymphoma. Hematopathology. 2000;113:391–8.

    Google Scholar 

  18. Antonio T, Giovanni B, Francesco C, et al. Detection of HCV RNA in gastric mucosa-associated lymphoid tissue by in situ hybridization : evidence of a new extrahepatic localization of HCV with increased risk of gastric Malt lymphoma. Am J Gastroenterol. 2002;97(7):1802–6.

    Google Scholar 

  19. Emilio I, Emanuele A, Claudio T, et al. Long-lasting remission of primary hepatic lymphoma and hepatitis C virus infection achieved by the alpha-interferon treatment. Hematol J. 2004;5:530–3.

    Article  Google Scholar 

  20. Hermine O, Lefrère F, Bronowicki JP, et al. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N Engl J Med. 2002;347(2):89–94.

    Article  PubMed  CAS  Google Scholar 

  21. Kelaidi C, Rollot F, Park S, et al. Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas. Leukemia. 2004;18(10):1711–6.

    Article  PubMed  CAS  Google Scholar 

  22. Vallisa D, Bernuzzi P, Arcaini L, et al. Role of anti-hepatitis C virus (HCV) treatment in HCV-related, low-grade, B-cell, non-Hodgkin’s lymphoma: a multicenter Italian experience. J Clin Oncol. 2005;23(3):468–73.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Hakodate Municipal Hospital, 1-10-1, Minato-cho, Hakodate, 041-8680, Japan

    Souichi Shiratori, Yutaka Tsutsumi, Takahito Kawamura & Nobuo Masauzi

  2. Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Souichi Shiratori, Junji Tanaka & Masahiro Imamura

  3. Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Yutaka Tsutsumi, Takahito Kawamura, Nobuo Masauzi & Masahiro Asaka

  4. Department of Clinical Pathology, Hakodate Municipal Hospital, Hakodate, Japan

    Kazuhiro Kudo & Norihiko Shimoyama

Authors
  1. Souichi Shiratori
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  2. Yutaka Tsutsumi
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  3. Takahito Kawamura
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  4. Kazuhiro Kudo
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  5. Norihiko Shimoyama
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  6. Nobuo Masauzi
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  7. Junji Tanaka
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  8. Masahiro Asaka
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  9. Masahiro Imamura
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Correspondence to Yutaka Tsutsumi.

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Shiratori, S., Tsutsumi, Y., Kawamura, T. et al. HCV non-structural protein 3 and HCV RNA genome in non-Hodgkin lymphoma and transition of the serum HCV RNA level: a retrospective analysis in one institution. Int J Hematol 87, 298–302 (2008). https://doi.org/10.1007/s12185-008-0050-2

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  • DOI: https://doi.org/10.1007/s12185-008-0050-2

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