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Paclitaxel induced chronic fibrosing interstitial pneumonitis: a case report and review of the literature

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Oncology Reviews

Abstract

Pulmonary toxicity is rarely associated with paclitaxel chemotherapy and its mechanism is not well known. This report describes one patient with pancreatic adenocarcinoma, metastatic neuroendocrine low-grade pancreatic tumor, and a concomitant stage I non-small cell lung cancer (NSCLC), who also developed life-threatening paclitaxel-induced chronic fibrosing interstitial pneumonitis. Giving the gravity of the condition and the not-well-established treatment, physicians should be aware of the possibility of chronic fibrosing interstitial lung disease during the course of paclitaxel containing regimens in patients who present with respiratory symptoms.

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Authors and Affiliations

  1. Hospital Sirio Libanes, Universidade de Sao Paulo, Rua Adma Jafet 91, Sao Paulo, SP, Brazil

    Renata Ferrarotto, Guilherme Schetino, Daniela Freitas, Vera Capelozzi & Paulo M. Hoff

  2. Instituto do Cancer do Estado de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil

    Paulo M. Hoff

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  1. Renata Ferrarotto
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  2. Guilherme Schetino
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  3. Daniela Freitas
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  4. Vera Capelozzi
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  5. Paulo M. Hoff
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Correspondence to Renata Ferrarotto.

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Ferrarotto, R., Schetino, G., Freitas, D. et al. Paclitaxel induced chronic fibrosing interstitial pneumonitis: a case report and review of the literature. Oncol Rev 4, 101–106 (2010). https://doi.org/10.1007/s12156-010-0043-2

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  • DOI: https://doi.org/10.1007/s12156-010-0043-2

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