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The clinical utility of 99mTc-HMPAO SPECT in Fahr’s disease

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Abstract

Fahr’s disease is a rare neurodegenerative syndrome, characterized by massive symmetrical intracerebral calcifications of the basal ganglia, dentate nuclei of the cerebellum, and the adjacent parenchyma. Computerized tomography (CT) is considerably more sensitive to detect these intracranial calcifications than other imaging modalities. The clinical, CT scan, and 99mTc-D,L-hexamethylpropylene amine oxime (99mTc-HMPAO) brain perfusion single-photon emission computerized tomography (SPECT) findings in a 42-year-old woman with Fahr’s disease are reported, and the clinical utility of 99mTc-HMPAO SPECT findings in Fahr’s disease is discussed in this article. In conclusion, 99mTc-HMPAO brain perfusion SPECT seems to be useful in the clinical approach to Fahr’s disease, and may provide more specific and clinically relevant information when compared with anatomical imaging.

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Authors and Affiliations

  1. Kayasultan Sokak, Aydogan Sitesi, No. 72, A Blok, Daire: 5, Kozyatagi, Istanbul, 34742, Turkey

    Tunc Ones

  2. Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, Turkey

    Tunc Ones, Fuat Dede, Hatice Memis, Tanju Y. Erdil, Sabahat Inanir & Halil T. Turoglu

  3. Department of Neurology, Marmara University School of Medicine, Istanbul, Turkey

    Dilek Gunal

  4. Department of Radiology, Marmara University School of Medicine, Istanbul, Turkey

    Gazanfer Ekinci

Authors
  1. Tunc Ones
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  2. Fuat Dede
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  3. Dilek Gunal
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  8. Halil T. Turoglu
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Correspondence to Tunc Ones.

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Ones, T., Dede, F., Gunal, D. et al. The clinical utility of 99mTc-HMPAO SPECT in Fahr’s disease. Ann Nucl Med 22, 425–428 (2008). https://doi.org/10.1007/s12149-007-0121-0

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  • DOI: https://doi.org/10.1007/s12149-007-0121-0

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