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Localized Nasopharyngeal Amyloidosis: A Clinicopathologic Series of 7 Cases with a Literature Review

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Abstract

Localized nasopharyngeal amyloidosis is an extremely rare entity with only 25 cases described in the English and German literature. We present a case series of seven patients with localized nasopharyngeal amyloidosis and combine the findings with a thorough review the literature.

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References

  1. Sipe JD, Benson MD, Buxbaum JN, Ikeda SI, Merlini G, Saraiva MJ, Westermark P. Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines. Amyloid. 2016;23(4):209–13.

    Article  CAS  Google Scholar 

  2. Nienhuis HL, Bijzet J, Hazenberg BP. The prevalence and management of systemic amyloidosis in Western Countries. Kidney Dis. 2016;2(1):10–9.

    Article  Google Scholar 

  3. Sipe JD, Benson MD, Buxbaum JN, Ikeda S, Merlini G, Saraiva MJ, Westermark P. Nomenclature 2014: amyloid fibril proteins and clinical classification of the amyloidosis. Amyloid. 2014;21:221–4.

    Article  Google Scholar 

  4. Hazenberg BP. Amyloidosis: a clinical overview. Rheum Dis Clin North Am. 2013;39:323–45.

    Article  Google Scholar 

  5. Glenner GG. Amyloid deposits and amyloidosis: the beta-fibrilloses. N Engl J Med. 1980;302:1283–92, 1333–43.

    Article  CAS  Google Scholar 

  6. Scott PP, Scott WW, Siegelman SS. Amyloidosis: an overview. SeminRoentgenol. 1986;21:103–12.

    CAS  Google Scholar 

  7. Panda N, Saravanan K, Purushotaman G, Gurunathan R, Mahesha V. Localized amyloidosis masquerading as nasopharyngeal tumor: a review. Am J Otolaryngol-Head Neck Surg. 2007;28:208–11.

    Google Scholar 

  8. Yoshida A, Borkar S, Singh B, Ghossein RA. Schöder H Incidental detection of concurrent extramedullary plasmacytoma and amyloidoma of the nasopharynx on [18F] fluorodeoxyglucose positron emission tomography/computed tomography. J Clin Oncol. 2008;26(35):5817–9.

    Article  Google Scholar 

  9. Kramer R, Som ML. Local tumor-like deposits of amyloid in thelarynx. Report of a case and review of the literature. Arch Otolaryngol 1935;21:324–34.

    Article  Google Scholar 

  10. Johner CH, Widen AH, Soghol S. Amyloidosis of the head and neck. Trans Pa Acad Ophthalmol Otol. 1972;76:1354–5.

    CAS  Google Scholar 

  11. Simpson GT, Strong MS, Skinner M, et al. Localized amyloidosis of the head and neck, upper and lower respiratory tracts. Ann OtolRhinol Laryngol. 1984;93:374–9.

    Article  Google Scholar 

  12. Zack Zonk MS. Unusual etiology of unilateral glue ear in a child. J Laryngol Otol. 1984;98:519–22.

    Google Scholar 

  13. Gean-Marton AD, Clandia FE, Kirsch BS, et al. Focal amyloidosis of the head and neck: evaluation with CT and MR imaging. Radiology. 1991;181:521–5.

    Article  CAS  Google Scholar 

  14. Hegarty JL, Rao VM. Amyloidoma of the nasopharynx: CT and MR findings. AJNR Am J Neuroradiol. 1993;114:215–8.

    Google Scholar 

  15. Panda NK, Sharma SC, Mann SB, et al. Localized amyloidosis of the nasopharynx. ENT J. 1994;75:335–6.

    Google Scholar 

  16. Dominguez S, Wienberg P, Claros P, et al. Primary localized nasopharyngeal amyloidosis. A case report. Int J Pediatr Otorhinolaryngol. 1996;36:61–7.

    Article  CAS  Google Scholar 

  17. Lim JS, Lebowitz RA, Jacob JB. Primary amyloidosis presenting as a nasopharyngeal mass. Am J Rhinol. 1999;13:209–12.

    Article  CAS  Google Scholar 

  18. Pitkaranta A, Malmberg H. Localized amyloid tumor of nasopharynx. Otolaryngol Head Neck Surg. 2000;122:309–10.

    Article  CAS  Google Scholar 

  19. Munichor M, Cohen H, Kerner H, et al. Localized amyloidosis in nasopharyngeal carcinoma diagnosed by fine needle aspiration and electron microscopy. A case report. Acta Cytol. 2000;44:673–8.

    Article  CAS  Google Scholar 

  20. Patel A, Pombuccian S, Maisel R. Nasopharyngeal amyloidosis. Am J Otolaryngol 2002;23:308–11.

    Article  Google Scholar 

  21. Zhuang YL, Tsai TL, Lin CZ. Localized amyloid deposition in the nasopharynx and neck, mimicking nasopharyngeal carcinoma with neck metastasis. J Chin Med Assoc. 2005;68(3):142–5.

    Article  Google Scholar 

  22. Motosugi U, Ichikawa T, Araki T, Endo S, Masuyama K, Nakazawa T. Localized nasopharyngeal amyloidosis with remarkable early enhancement on dynamic contrast-enhanced MR imaging. Eur Radiol. 2007;17(3):852–3.

    Article  Google Scholar 

  23. Chen YS, Li WY, Ho CY. Localized nasopharyngeal amyloidosis. J Chin Med Assoc. 2010;73(10):549–52.

    Article  Google Scholar 

  24. Wu AY, Chapman WB, Witterick IJ, Deangelis DD. Bifocal orbital and nasopharyngeal amyloidomas presenting as Graves disease. Ophthal Plast Reconstr Surg. 2011;27(5):e132–e4.

    Article  Google Scholar 

  25. Karimi K, Chheda NN. Nasopharyngeal amyloidosis: a case report. Laryngoscope 2010;120(Suppl 4):S197.

    Article  Google Scholar 

  26. Durbec M, Ambrun A, Barnoud R, Poupart M, Pignat JC, Merrot O. Localized nasopharyngeal amyloidosis. Eur Ann Otorhinolaryngol Head Neck Dis. 2012;129(3):160–2.

    Article  CAS  Google Scholar 

  27. Legaza ES, Oliver CC, Cauqui RG. Amyloidosis of the nasopharynx. Acta Otorrinolaringol Esp. 2013;64(5):377–8.

    Article  Google Scholar 

  28. Mirza AH, El-Shunnar S, Sama A. Nasopharyngeal amyloidosis: an unusual cause of unilateral hearing loss. J Surg Case Rep. 2013;2013(2):rjs048.

    Article  Google Scholar 

  29. Kumar B, Pant B, Kumar V, Negi M. Sinonasal globular amyloidosis simulating malignancy: a rare presentation. Head Neck Pathol. 2016;10(3):379–83.

    Article  Google Scholar 

  30. Luo M, Peng G, Shi L, Ming X, Li Z, Fei S, Ding Q, Cheng J. Intensity-modulated radiotherapy for localized nasopharyngeal amyloidosis: case report and literature review. Strahlenther Onkol. 2016;192(12):944–50.

    Article  Google Scholar 

  31. Urban BA, Fishman EK, Goldman SM, Scott WW, Jones B, Humphrey RL, Hruban RH. CT evaluation of amyloidosis: spectrum of disease. Radiographics 1993;13:1295–308.

    Article  CAS  Google Scholar 

  32. Nandapalan V, Jones TM, Morar P, Clark AH, Jones AS. Localized amyloidosis of the parotid gland: a case report and review of the localized amyloidosis of the head and neck. Head Neck. 1998;20(1):73–8.

    Article  CAS  Google Scholar 

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Correspondence to Georgios Sakagiannis.

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All authors declare that he/she has not conflict of interest as it relates to this research project.

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All procedures performed in this retrospective data analysis involving human participants were in accordance with the ethical standards of the institutional review board, which did not require informed consent.

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Sakagiannis, G., Giotakis, E. & Thompson, L.D.R. Localized Nasopharyngeal Amyloidosis: A Clinicopathologic Series of 7 Cases with a Literature Review. Head and Neck Pathol 12, 542–547 (2018). https://doi.org/10.1007/s12105-017-0880-4

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  • DOI: https://doi.org/10.1007/s12105-017-0880-4

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