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IgM Nephropathy in India: A Single Centre Experience

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Abstract

Objective

To find out the incidence and natural history of IgMN in India.

Methods

Renal biopsies of children ≤12 y age of last 6 y were retrospectively evaluated. Their clinical and biochemical presentation were correlated. Patients with systemic diseases/disorders were excluded from the study.

Results

Immunoglobulin M nephropathy (IgMN) constituted 11.9% (n = 28) of 236 renal biopsies. Mean age was 10 y, predominant in boys (n = 24), most of the patients presented with proteinuria and edema. The most common associated histopathological finding was mesangial proliferative glomerulonephritis (MePGN) in 60.7% (n = 17) followed by minimal change disease (MCD) in 28.6% (n = 8) and focal segmental glomerulosclerosis (FSGS) in 10.7% (n = 3). In 85.7%, IgM appeared as the sole immunoglobulin deposit mainly in mesangial regions, followed by accompanied C3 in 3.6% (n = 1) and C1q + C3 in 10.7% (n = 3) biopsies.

Conclusions

IgMN was observed in 11.9% biopsies with commonest morphology of MePGN followed by MCD and FSGS; proteinuria was bad prognosticator in addition to FSGS and co-deposition of other immunoglobulins had no significance.

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Abbreviations

FSGS:

Focal and Segmental Glomerulosclerosis

IF:

Immunofluorescence

IgMN:

IgM Nephropathy

LM:

Light Microscopy

MCD:

Minimal Change Disease

MePGN:

Mesangial Proliferative Glomerulonephritis

SCr:

Serum Creatinine

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Authors and Affiliations

  1. Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad, 380016, Gujarat, India

    Aruna V. Vanikar, Kamal V. Kanodia, Rashmi D. Patel & Kamlesh S. Suthar

  2. Department of Nephrology and Transplantation Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC)- Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India

    Himanshu V. Patel, Manoj R. Gumber & Hargovind L. Trivedi

Authors
  1. Aruna V. Vanikar
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  2. Kamal V. Kanodia
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  3. Rashmi D. Patel
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  4. Kamlesh S. Suthar
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  5. Himanshu V. Patel
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  6. Manoj R. Gumber
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  7. Hargovind L. Trivedi
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Corresponding author

Correspondence to Aruna V. Vanikar.

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Vanikar, A.V., Kanodia, K.V., Patel, R.D. et al. IgM Nephropathy in India: A Single Centre Experience. Indian J Pediatr 79, 1025–1027 (2012). https://doi.org/10.1007/s12098-012-0693-0

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  • DOI: https://doi.org/10.1007/s12098-012-0693-0

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