Abstract
Infections are the single largest cause of neonatal deaths globally. According to National Neonatal Perinatal Database (2002–03), the incidence of neonatal sepsis in India was 30 per 1000 live-births; klebsiella pneumoniae and staphylococcus aureus were the two most common organisms isolated. Based on the onset, neonatal sepsis is classified into two major categories: early onset sepsis, which usually presents with respiratory distress and pneumonia within 72 hours of age and late onset sepsis, that usually presents with septicemia and pneumonia after 72 hours of age. Clinical features of sepsis are non-specific in neonates and a high index of suspicion is required for the timely diagnosis of sepsis. Although blood culture is the gold standard for the diagnosis of sepsis, culture reports would be available only after 48–72 hours. A practical septic screen for the diagnosis of sepsis has been described and some suggestions for antibiotic use have been included in the protocol.
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References
Bang AT, Bang RA, Bactule SB, Reddy HM, Deshmukh MD. Effect of home-based neonatal care and management of sepsis on neonatal mortality: field trial in rural India. Lancet 1999; 354: 1955–19861.
Stoll BJ. The global impact of neonatal infection. Clin Perinatol 1997; 24: 1–21.
Report of the National Neonatal Perinatal Database (National Neonatology Forum) 2002–2003.
Singh M, Narang A, Bhakoo ON. Predictive perinatal score in the diagnosis of neonatal sepsis. J Trop Pediatr 1994; 40: 365–368.
Takkar VP, Bhakoo ON, Narang A. Scoring system for the prediction of early neonatal infections. Indian Pediatr 1974; 11: 597–600
Baltimore RS. Neonatal nosocomial infections. Semin Perinatol 1998; 22: 25–32.
Wolach B. Neonatal sepsis: pathogenesis and supportive therapy. Semin Perinatol 1997; 21: 28–38.
Gerdes JS, Polin R. Early diagnosis and treatment of neonatal sepsis. Indian J Pediatr 1998; 65: 63–78.
Polinski C. The value of white blood cell count and differential in the prediction of neonatal sepsis. Neonatal Netw 1996; 15: 13–23
Da Silva O, Ohlsson A, Kenyon C. Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review. Pediatr Infect Dis J 1995; 14: 362–366.
Manroe BL, Weinberg AG, Rosenfeld CR, Browne R. The neonatal blood count in health and disease. I. Reference values for neutrophilic cells. J Pediatr 1979; 95: 89–98.
Mouzinho A, Rosenfeld CR, Sanchez PJ, Risser R. Revised reference ranges for circulating neutrophils in very-low-birth-weight neonates. Pediatrics 1994; 94: 76–82.
Sarff LD, Platt LH, McCracken GH Jr. Cerebrospinal fluid evaluation in neonates: Comparison of high-risk neonates with and without meningitis. J Pediatr 1976; 88: 473–477.
Upadhyay A, Aggarwal R, Kapil A, Singh S, Paul VK, Deorari AK. Profile of neonatal sepsis in a tertiary care neonatal unit from India: A retrospective study. J Neonatology 2006; 20: 50–57.
Deorari Ashok K. For the Investigators of the National Neonatal Perinatal Database (NNPD). Changing pattern of bacteriologic profile in Neonatal Sepsis among intramural babies. J Neonatology 2006; 20: 8–15.
Zaidi AK, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. Hospital-acquired neonatal infections in developing countries. Lancet 2005; 365: 1175–1188.
Sadana S, Mathur NB, Thakur A. Exchange transfusion in septic neonates with sclerema: effect on immunoglobulin and complement levels. Indian Pediatr 1997; 34: 20–25.
Jenson HB, Pollock HB. The role of intravenous immunoglobulin for the prevention and treatment of neonatal sepsis. Semin Perinatol 1998; 22: 50–63.
Goldman S, Ellis R, Dhar V, Cairo MS. Rationale and potential use of cytokines in the prevention and treatment of neonatal sepsis. Clin Perinatol 1998; 25: 699–710.
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Sankar, M.J., Agarwal, R., Deorari, A.K. et al. Sepsis in the newborn. Indian J Pediatr 75, 261–266 (2008). https://doi.org/10.1007/s12098-008-0056-z
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DOI: https://doi.org/10.1007/s12098-008-0056-z