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The epidemiology of laryngeal cancer in a country on the esophageal cancer belt

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Objective

Laryngeal cancer is one of the most common malignant neoplasms of the head and neck and occurs predominantly in males. Squamous cell carcinomas arising in the glottic region are the most common of all laryngeal cancers and more prevalent than the supraglottic ones. But this pattern is reverse in some countries. This study was done to investigate the epidemiologic aspect of this subject in Iran.

Study design

Cross-sectional study

Subjects and methods

During a ten-year period from 1997 to 2007, all patients referred to two tertiary referral hospitals with a diagnosis of laryngeal cancer were enrolled in this study.

Results

Laryngeal cancer was diagnosed in a total of 453 patients and confirmed histologically. The average patient age was 59.92 years. Men outnumbered women (9.5:1). Four hundred patients (88.5%) were tobacco smokers. The primary location of the tumor was supraglottic in 221 (49%) cases, followed by glottic in 163 (36.2%), transglottic (the tumor involved all regions of the larynx and the origin was unspecified) in 60 (13.3%), and subglottic in 7 (1.6%).

Conclusion

In our series, although we excluded transglottic tumors, the supraglottic tumor was dominant and the ratio of supraglottic to glottic tumors was 1.36. This is compatible with results from countries with a reverse ratio.

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References

  1. G Severi IP, Robertson C, Boyle P (1999) Larynx cancer in Slovakia and the role of anatomical subsites. Oral Oncol 35(4):564–570

    Article  Google Scholar 

  2. Cattaruzza M, Boyle P (1996) Epidemiology of laryngeal cancer, European J Cancer Part B. Oral Oncol 32(5): 293–305

    Google Scholar 

  3. Raitiola A, Virtaniemi K, Grénman R (1999) Changing trends in the occurrence and subsite distribution of laryngeal cancer in Finland. Eur Arch Otorhinolaryngol 25(4): 277–279

    Google Scholar 

  4. Eduardo De Stefani PB, Deneo-Pellegrini H, Brennan P, Correa P, Oreggia F (2004) Supraglottic and glottic carcinomas: Epidemiologically distinct entities? Epidemiology 2(5):134–137

    Google Scholar 

  5. Hannu, Raiyiola J (1999) Glottic and Supraglottic Laryngeal Carcinoma: Differences in Epidemiology, Clinical Characteristics and Prognosis. Acta Otolaryngol (Stockh). 119(3): 847–851

    Google Scholar 

  6. Silvano CB, Silvia F Fabio EN, Carlo La (2003) Laryngeal Cancer in Women: Tobacco, Alcohol, Nutritional, and Hormonal Factors. Cancer Epidemiology, Biomarkers & Prevention 12(4):514–517

    Google Scholar 

  7. Lisa Licitra A JBb, Cesare Grandi C, Laura Locati D, Marco Merlano E, Gemma Gatta D J-LL (2003) Cancer of the larynx. Crit Rev Oncol/Hematol 47(5):65–80

    Article  Google Scholar 

  8. Patti A. Groome KS, Morten Boysen, Stephen F. Hall, et al. (2002) A comparison of published head and neck stage groupings in laryngeal cancer using data from two countries. J Clin Epidemiol 55:533–544

    Article  Google Scholar 

  9. Louise Davies M, and Gilbert Welch H (2006) Epidemiology of head and neck cancer in the United States. Otolaryngol Head Neck Surgery 135:451–457

    Article  Google Scholar 

  10. Hoffman HT, FACS; Porter K ( 2006) Laryngeal cancer in the United States: Changes in demographics, patterns of care, and survival laryngoscope 116(9):1–13

    Google Scholar 

  11. Rafferty MAF, Jones AS (2006) The history, etiology and epidemiology of laryngeal carcinoma. Clin Otolaryngol Allied Sci 26(6):442–446

    Google Scholar 

  12. Dosemeci MG, I Unsal, M Hayes, RB Blair A (1997) Tobacco, alcohol use, and risks of laryngeal and lung cancer by subsite and histologic type in Turkey. Cancer Causes Control 8(5):729–737

    Article  PubMed  CAS  Google Scholar 

  13. Day NE (1975) Some Aspects of the Epidemiology of Esophageal Cancer. Cancer Res 35(2):3304–3307

    PubMed  CAS  Google Scholar 

  14. Christian C, Abnet MS-E, Akram Pour Shams (2004) Reliability and validity of opiate use self-report in a population at high risk for esophageal cancer in Golestan, Iran. Cancer Epidemiol Biomarkers Prevention 13(6):1068–1070

    Google Scholar 

  15. Sepehra FK, Christian C, Abneta, Saman F (2004) Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison. Cancer Lett 213(2):195–202

    Article  Google Scholar 

  16. Russo AFS The epidemiology of esophageal cancer (1996); Ann IST Super Sanita 32(1):65–72

    PubMed  CAS  Google Scholar 

  17. Mousavi M, Haghdoust MA, Akbar A, Khamesipour (2003) Opium and risk of laryngeal cancer. Laryngoscope 113(11): 1939–1943

    Article  PubMed  Google Scholar 

  18. R. Passable MU, Fustians, et al. (2002) Risk factors for esophageal, lung, and laryngeal cancer in black South Africa. Br J Cancer 86:1751–1756

    Article  Google Scholar 

  19. Mia Hashibe PB, David Zaridze, Oxana Shangina, Neonila Szeszenia-Dabrowska,, Dana Mates ErFn, Peter Rudnai, and Paul Brennan (2007);. Contribution of Tobacco and Alcohol to the High Rates of Squamous Cell Carcinoma of the Supraglottis and Glottis in Central Europe. Am J Epidemiology 165:814–820

    Article  Google Scholar 

  20. Y. Shimizu HT, M, Fujita, et al. (2003) Head and neck cancer arising after endoscopic mucosal resection for squamous cell carcinoma of esophagus. Endoscopy 35(4):322–326

    Article  Google Scholar 

  21. Cann CIF, M P. Rothman KJ (1985) Epidemiology of squamous cell cancer of the head and neck. Otolaryngol Clin North Am 18(3):367–388

    PubMed  CAS  Google Scholar 

  22. Rothman KJ (1978) Epidemiology of head and neck cancer. Laryngoscope 88(3):435–438

    Article  PubMed  CAS  Google Scholar 

  23. Yang PCT, D B. Daling, J R. Davis S (1989) Differences in the sex ratio of laryngeal cancer incidence rates by anatomic subsite. J Clin Epidemiol 42(8):755–758

    Article  PubMed  CAS  Google Scholar 

  24. T. KrcÎecicki a MZ-Ka, M. Jagas b, K. Szajowski c, J. Raka. (1998) Laryngeal cancer in Lower Silesia: descriptive analysis of 501 cases. Oral Oncology 34(2):377–380

    Google Scholar 

  25. Wunsch Filho V (2004) The epidemiology of laryngeal cancer in Brazil. Sao Paulo Med J 188–94(3):122(5)

    Google Scholar 

  26. Oxana Shangina PB, Neonila Szeszenia-Dabrowska, Dana Mates (2006) Occupational exposure and laryngeal and hypopharyngeal cancer risk in central and eastern europe. Am J Epidemiol 164(4):367–375

    Article  PubMed  Google Scholar 

  27. Eva Munck-Wikland · Antti A. Mäkitie · Ilmari Pyykkö (2007) Alcohol, smoking and human papillomavirus in laryngeal carcinoma: a Nordic prospective multicenter study. Cancer Res Clin Oncol 133:673–678

    Article  Google Scholar 

  28. A. Bacciu GM, A. Ingegnoli, T. Ferri, P. Muzzetto, G. Leanadro, F. DimarioI and S. Bacciu (2004) Effects of gastroesophageal reflux disease in laryngeal carcinoma. Clin Otolaryngol 29:545–548

    Article  Google Scholar 

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Authors and Affiliations

  1. Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

    Babak Saedi, Ebrahim Razmpa, Mohammad Sadeghi, Mohammad Mojtahed & Ali Mojtahed

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  1. Babak Saedi
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  2. Ebrahim Razmpa
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  3. Mohammad Sadeghi
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  4. Mohammad Mojtahed
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  5. Ali Mojtahed
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Correspondence to Babak Saedi.

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Saedi, B., Razmpa, E., Sadeghi, M. et al. The epidemiology of laryngeal cancer in a country on the esophageal cancer belt. Indian J Otolaryngol Head Neck Surg 61, 213–217 (2009). https://doi.org/10.1007/s12070-009-0069-6

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