Abstract
Six new Ru(II) and Ru(III) complexes have been synthesized and characterized by elemental analysis, LC-MS, electronic spectra, IR spectra and magnetic moment measurements. DNA-binding properties of Ru complexes have been studied by means of absorption spectrophotometry and viscosity measurements as well as their HS DNA cleavage properties by means of agarose gel electrophoresis. The experimental results show that all the complexes can bind to DNA via partial intercalative mode. The K b values of complexes were found in the range 2.14 × 10 4 to 2.70 × 10 5 M−1. All the complexes show excellent efficiency of cleaving DNA than respective fluoroquinolones. Brine shrimp lethality bioassay has been performed to check the cytotoxic activity. The IC 50 values of the complexes are in the range of 6.27 to 16.05 μg mL−1.
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The authors thank the Head, Department of Chemistry, Sardar Patel University, India, for making it convenient to work in laboratory facility.
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PATEL, M.N., JOSHI, H.N. & PATEL, C.R. Cytotoxic, DNA binding, DNA cleavage and antibacterial studies of ruthenium–fluoroquinolone complexes. J Chem Sci 126, 739–749 (2014). https://doi.org/10.1007/s12039-014-0597-9
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DOI: https://doi.org/10.1007/s12039-014-0597-9