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A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina

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Abstract

The Müller cells represent the predominant macroglial cell in the retina. In recent decades, Müller cells have been acknowledged to be far more influential on neuronal homeostasis in the retina than previously assumed. With its unique localization, spanning the entire retina being interposed between the vessels and neurons, Müller cells are responsible for the functional and metabolic support of the surrounding neurons. As a consequence of major energy demands in the retina, high levels of glucose are consumed and processed by Müller cells. The present review provides a perspective on the symbiotic relationship between Müller cells and inner retinal neurons on a cellular level by emphasizing the essential role of energy metabolism within Müller cells in relation to retinal neuron survival.

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Authors and Affiliations

  1. Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark

    A. K. Toft-Kehler, D. M. Skytt & Miriam Kolko

  2. Department of Ophthalmology, Zealand University Hospital, Vestermarksvej 23, 4000, Roskilde, Denmark

    Miriam Kolko

  3. Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet, Nordre Ringvej 57, 2600, Glostrup, Denmark

    Miriam Kolko

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  1. A. K. Toft-Kehler
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Toft-Kehler, A.K., Skytt, D.M. & Kolko, M. A Perspective on the Müller Cell-Neuron Metabolic Partnership in the Inner Retina. Mol Neurobiol 55, 5353–5361 (2018). https://doi.org/10.1007/s12035-017-0760-7

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