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Proliferating Cell Nuclear Antigen Has an Association with Prognosis and Risks Factors of Cancer Patients: a Systematic Review

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Abstract

Proliferating cell nuclear antigen (PCNA) is reported as a famous marker in various tumors. A couple of articles have been published about the clinical function of PCNA on cancer progression; however, these results are conflicting in some degree. Thus, it is crucial to perform a systematic review and meta-analysis to identify their real actions. Here, we took cervical cancer and glioma as example and then pooled hazard ratios (HRs) or odds ratios (ORs) with 95 % confidence intervals (95 % CIs). In the present study, the PCNA expression in cervical cancer and gliomas patients was both correlated with 5-year-overall survival (OS) (HR = 4.41, 95 % CI 2.71–7.17, p = 0.000; HR = 4.40, 95 % CI 3.00–6.47, p = 0.000; respectively). In addition, a fixed effect model revealed a significant association between PCNA and FIGO stage (OR = 4.48, 95 % CI 3.48–5.77, p = 0.000) or WHO grade (OR = 5.64, 95 % CI 4.15–7.68, p = 0.000), rather than age (OR = 1.01, 95 % CI 0.71–1.43, p = 0.957; OR = 1.00, 95 % CI 0.80–1.24, p = 0.989; respectively). No heterogeneity was observed across all studies. According to funnel plot, no publication bias was reported. In conclusion, our systematic review suggests that PCNA expression is significantly associated with poor 5-year survival, advanced stage or higher WHO grade, which might be suggested as a useful prognostic and diagnostic biomarker, or an effective therapy target in cervical cancer, gliomas, or even more cancers.

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Acknowledgments

We greatly thank other members in our lab for valuable suggestions and writing.

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Authors and Affiliations

  1. First Department of Gynaecology, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuhan, 430060, Hubei, China

    Qiongying Lv, Juan Zhang, Yuexiong Yi, Yue Huang, Yong Wang, Yijun Wang & Wei Zhang

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  1. Qiongying Lv
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  2. Juan Zhang
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  3. Yuexiong Yi
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  4. Yue Huang
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  5. Yong Wang
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  7. Wei Zhang
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Correspondence to Wei Zhang.

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Lv, Q., Zhang, J., Yi, Y. et al. Proliferating Cell Nuclear Antigen Has an Association with Prognosis and Risks Factors of Cancer Patients: a Systematic Review. Mol Neurobiol 53, 6209–6217 (2016). https://doi.org/10.1007/s12035-015-9525-3

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  • DOI: https://doi.org/10.1007/s12035-015-9525-3

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