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Radial Glia, the Keystone of the Development of the Hippocampal Dentate Gyrus

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Abstract

The morphogenesis of the dentate gyrus (DG) of the hippocampus primarily occurs postnatally, and the DG is one of the few regions of continuous neurogenesis in the adult brain. Radial glial cells (RGCs), which contribute to DG development by participating in key steps of morphogenesis, are maintained in the subgranular zone (SGZ), where they play pivotal roles in adult hippocampal neurogenesis. It is clear that a series of molecules control the development of RGCs, thereby regulating the morphogenesis of the DG and neurogenesis in the adult hippocampus. In this review, we provide an updated framework regarding the molecular mechanisms involved in the development of RGCs during DG morphogenesis and discuss the key steps that regulate DG formation.

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Acknowledgments

This study was supported by the National Nature Science Foundation of China (No. 81371197, 31271051), Natural Science Foundation Project of CQ CSTC 2013jjB10028.

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Authors and Affiliations

  1. Southwest Eye Hospital, Southwest Hospital, Third Military Medical University, 400038, Chongqing, People’s Republic of China

    Le Xu & Haiwei Xu

  2. The Battalion 5 of Cadet Brigade, Third Military Medical University, 400038, Chongqing, People’s Republic of China

    Le Xu

  3. Department of Histology and Embryology, Third Military Medical University, 400038, Chongqing, People’s Republic of China

    Xiaotong Tang, Ying Wang & Xiaotang Fan

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  1. Le Xu
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  2. Xiaotong Tang
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  3. Ying Wang
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  4. Haiwei Xu
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Correspondence to Haiwei Xu or Xiaotang Fan.

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Xu, L., Tang, X., Wang, Y. et al. Radial Glia, the Keystone of the Development of the Hippocampal Dentate Gyrus. Mol Neurobiol 51, 131–141 (2015). https://doi.org/10.1007/s12035-014-8692-y

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  • DOI: https://doi.org/10.1007/s12035-014-8692-y

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