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Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) Gene Associated with Treatment Response to Mood Stabilizers in Patients with Bipolar I Disorder

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Abstract

There is increasing evidence supporting the relationship between bipolar disorder (BP) and neurotrophin. The present study investigated the relationship between neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene polymorphisms and bipolar I disorder (BP I) susceptibility and treatment response to mood stabilizers (lithium or valproate). Two-hundred eighty-four patients who met the DSM-IV criteria for BP I and 295 matched healthy controls were enrolled into this study. TaqMan® SNP genotyping assays were applied to genotype three NTRK2 gene polymorphisms (rs2769605, rs1565445, rs1387923). Our study showed a significant allelic association between NTRK2 gene polymorphism rs2769605 and treatment response to mood stabilizers in BP I patients (t = −2.53, P = 0.01). However, no significant association between NTRK2 gene polymorphisms and BP I susceptibility was observed after correcting for multiple comparisons. The results suggest that the NTRK2 gene polymorphism likely plays an essential role in treatment response to mood stabilizers in Han Chinese BP I patients.

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Acknowledgments

Funding for this study was provided by the National Natural Science Foundation of China (grant no. 30971047), Shanghai Jiaotong University School of Medicine Training Program for Excellent Doctoral Dissertation (grant no. YBPY2010010), Shanghai Key Medicine Specialties Program (grant no. ZK2012A12), Key Medicine Specialties Program of Hongkou District (grant no. Hongkou Health [2010]91) and Hongkou District Medicine Study Program (grant no. Hongkou Health 1101-02). Partial support was received from the “12th Five-year Plan” of the National Key Technologies R&D Program (2012BAI01B04) and the National Key Clinical Disciplines at Shanghai Mental Health Center (OMA-MH2011-873). The authors thank Joseph R. Calabrese from Case Western Reserve University School of Medicine and Martin Alda from Dalhousie University for the permission of using the scale “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorders.” The authors also express their gratitude to Mrs. Mary Beth Serrano from Case Western Reserve University for grammatical assistance.

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Authors and Affiliations

  1. Department of Psychiatry, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People’s Republic of China

    Zuowei Wang, Zezhi Li, Zhenghui Yi, Lingxiao Wang, Jia Huang, Chengmei Yuan, Wu Hong & Yiru Fang

  2. Department of Psychiatry, Hongkou District Mental Health Center of Shanghai, 159 Tong Xin Road, Shanghai, 200083, People’s Republic of China

    Zuowei Wang

  3. Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Jinbo Fan

  4. Department of Psychiatry, Mood and Anxiety Clinic in the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA

    Jinbo Fan & Keming Gao

  5. Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Shunying Yu

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  1. Zuowei Wang
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  2. Jinbo Fan
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  3. Keming Gao
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  4. Zezhi Li
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  5. Zhenghui Yi
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  6. Lingxiao Wang
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  7. Jia Huang
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  8. Chengmei Yuan
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  9. Wu Hong
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  10. Shunying Yu
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  11. Yiru Fang
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Correspondence to Zuowei Wang or Yiru Fang.

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Wang, Z., Fan, J., Gao, K. et al. Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) Gene Associated with Treatment Response to Mood Stabilizers in Patients with Bipolar I Disorder. J Mol Neurosci 50, 305–310 (2013). https://doi.org/10.1007/s12031-013-9956-0

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  • DOI: https://doi.org/10.1007/s12031-013-9956-0

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