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Comparison of the Expression of Cell Adhesion Molecule Markers (E-Cadherin and Syndecan-1) between Young and Older Age Patients with Gastric Carcinoma

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Abstract

Aim

The aim of this study was to evaluate the relationship between age and cell adhesion molecule markers (E-cadherin and syndecan-1)

Materials and Methods

Forty-three cases of gastric carcinoma below the age of 50 were referred to our center in the period of 5 years (2003–2008). Forty-three gastric carcinoma above the age of 50 years were sex-matched with the first group. Expression of syndecan-1 and E-cadherin were evaluated by immunohistochemistry in a total of 86 gastric carcinomas accompanying with all the clinicopathological findings in each case.

Results

The expression of syndecan-1and E-cadherin did not show significant difference between two age groups; in addition, there were no significant differences in all the clinicopathological findings in these two age groups.

Discussion

Gastric carcinoma in young and old age adults showed no significant difference in respect of the expression of cell adhesion molecule markers. Our result shows that young age alone cannot be predictive of more metastasis and invasion potential.

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Authors and Affiliations

  1. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, PO Box 71345-1864, Iran

    Bita Geramizadeh & Marjan Rahsaz

  2. Department of Pathology, Shiraz University of Medical Sciences, Shiraz, PO box 71345-1864, Iran

    Bita Geramizadeh, Omid-Ali Adeli, Maral Mokhtari & Salma Sefidbakht

Authors
  1. Bita Geramizadeh
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  2. Omid-Ali Adeli
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  3. Marjan Rahsaz
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  4. Maral Mokhtari
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  5. Salma Sefidbakht
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Correspondence to Bita Geramizadeh.

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Geramizadeh, B., Adeli, OA., Rahsaz, M. et al. Comparison of the Expression of Cell Adhesion Molecule Markers (E-Cadherin and Syndecan-1) between Young and Older Age Patients with Gastric Carcinoma. J Gastrointest Canc 41, 193–196 (2010). https://doi.org/10.1007/s12029-010-9149-9

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  • DOI: https://doi.org/10.1007/s12029-010-9149-9

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