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Serum Levels of Vitamin D, Calcium, Magnesium, and Copper, and their Relations with Mental Health and Sexual Function in Pregnant Iranian Adolescents

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Abstract

Pregnant adolescents are at risk for micronutrient deficiency, psychological problems, and sexual dysfunction. We aimed to determine serum levels of vitamin D, calcium, magnesium, and copper, and also their relations with stress, anxiety, depression, and sexual function in pregnant adolescents. This cross-sectional study was conducted on two hundred 11–19-year-old healthy singleton pregnant women at gestational age of 26–32 weeks, who were covered by public health centers in Tabriz, Iran. Depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS), anxiety and stress using the Depression, Anxiety and Stress Scale-21 (DASS-21), and sexual function using the Female Sexual Function Index (FSFI). The independent t test was employed to determine the relations. Serum levels of vitamin D were found to be deficient (< 20 ng/ml) in 59% of the participants and insufficient (20–29 ng/ml) in 33%. Normal serum levels of calcium were observed in 67% of the participants, those of magnesium in 89.5%, and those of copper in 86%. Moreover, moderate-to-severe anxiety was observed in 38.5%, moderate-to-severe stress in 22.5%, depression in 30%, and sexual dysfunction in 68%. Mean serum level of copper was higher in women with depression compared with those with no depression (100.6 vs 93.0, P = 0.048). No other statistically significant associations were found between serum levels of any of the micronutrients and anxiety, stress, depression, and sexual dysfunction (P > 0.05). The present study indicates high prevalence of micronutrient (especially vitamin D) deficiency, psychological problems, and sexual dysfunction among the pregnant adolescents. It also indicates an association between high serum copper level and depression.

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Funding

Financial support was provided by the deputy of research of Tabriz University of Medical Sciences.

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Authors and Affiliations

  1. Students’ Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran

    Parishan Bahramy & Fatemeh Ramezani-Nardin

  2. Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Sakineh Mohammad-Alizadeh-Charandabi

  3. Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran

    Mojgan Mirghafourvand

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  1. Parishan Bahramy
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Correspondence to Sakineh Mohammad-Alizadeh-Charandabi.

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This study was approved by the Ethics Committee of Tabriz University of Medical Sciences (Code: IR.TBZMED.REC.1397.54; date: 2018-10-10).

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Bahramy, P., Mohammad-Alizadeh-Charandabi, S., Ramezani-Nardin, F. et al. Serum Levels of Vitamin D, Calcium, Magnesium, and Copper, and their Relations with Mental Health and Sexual Function in Pregnant Iranian Adolescents. Biol Trace Elem Res 198, 440–448 (2020). https://doi.org/10.1007/s12011-020-02109-8

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