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Current Treatment Strategies and Future Treatment Options for Dravet Syndrome

  • Pediatric Neurology (A Yeshokumar, Section Editor)
  • Published:
Current Treatment Options in Neurology Aims and scope Submit manuscript

Abstract

Purpose of review

Dravet syndrome is a rare but severe genetic epilepsy that has unique treatment challenges. This is a review of current and future potential treatment options.

Recent findings

Treatment for Dravet syndrome should encompass many aspects of the syndrome such as gait, behavior, and nutrition, as well as focus on seizure control. Many sodium channel blockers should be avoided as they are likely to exacerbate seizures. Current options for treatment include valproic acid, clobazam, stiripentol, and ketogenic diet. Testing is underway for several new treatment options with unique mechanisms of action and therapeutic targets, including the serotonin system and genetic modulation.

Summary

Accurate and early diagnosis of Dravet syndrome will lead to avoidance of medications that may exacerbate seizures. Additionally, a multi-disciplinary approach and careful planning for management of episodes of status epilepticus may lead to improved outcomes. Ongoing research for novel approaches to treatment creates optimism for future improvement in outcomes.

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Correspondence to Kelly G. Knupp MD, MSCS, FAES.

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Conflict of Interest

Kelly G. Knupp reports grants from Zogenix Inc., grants from West Therapeutics, grants from Pediatric epilepsy research fund, personal fees from Stoke therapeutics, and grants from Colorado Department of Public Health, outside the submitted work. Joseph E. Sullivan reports grants from Zogenix, personal fees from Epygenix, and personal fees from Miller Medical, outside the submitted work; and Medical Advisory Board-Dravet Syndrome Foundation. Julie Ziobro and Krista Eschbach each declare no potential conflicts of interest.

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Ziobro, J., Eschbach, K., Sullivan, J.E. et al. Current Treatment Strategies and Future Treatment Options for Dravet Syndrome. Curr Treat Options Neurol 20, 52 (2018). https://doi.org/10.1007/s11940-018-0537-y

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