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Effects of Radiation on Bone

  • Osteoporosis and Cancer (P Taxel, Section Editor)
  • Published:
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Abstract

Ionizing radiation produces its deleterious biologic effects by both direct (DNA strand breaks) and indirect processes (formation of free oxygen radicals). Mitotically active cells are more susceptible to the detrimental effects of ionizing radiation. These effects are most severe locally within the treatment field but can also occur systemically, possibly reflecting hormonal influences and inflammatory cytokine mediators. Specific bone complications of radiation include osteopenia, growth arrest, fracture and malignancy. Some of these complications, such as osteopenia, are reversible and severity is dose dependent. Insufficiency fractures are a common complication after radiation therapy and generally affect those bones under most physiologic stress and with the highest ratio of trabecular to cortical bone. Familiarity with the radiographic appearance of irradiated bone, including computed tomography (CT) and magnetic resonance imaging (MRI), will improve image interpretation and facilitate accurate diagnosis.

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Conflict of Interest

R. Patheco declares that he has no conflicts of interest. H. Stock declares that he has no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-2802, USA

    Rafael Pacheco & Harlan Stock

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  1. Rafael Pacheco
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  2. Harlan Stock
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Correspondence to Harlan Stock.

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Pacheco, R., Stock, H. Effects of Radiation on Bone. Curr Osteoporos Rep 11, 299–304 (2013). https://doi.org/10.1007/s11914-013-0174-z

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