Abstract
West Nile virus appeared in New York City in 1999 and has subsequently spread over the eastern United States. The mode of transport across the Atlantic Ocean is unknown. During the past decade, encephalitis has been a more prominent feature of West Nile virus infection in Europe, the Middle East, and the United States, suggesting the emergence of more neurovirulent strains. The rapid spread of the virus and more serious disease caused by the virus have spurred vaccine development.
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Smithburn KC, Huges TP, Burke AW, Paul JH: A neurotropic virus isolated from the blood of a native of Uganda. Am J Trop M ed Hyg 1940, 20:471–492.
Work TH, Hurlbut AS, Taylor RM: Indigenous wild birds of the Nile Delta as potential West Nile virus circulating reservoirs. Am J Trop Med Hyg 1955, 4:872–887.
Melnick JL, Paul JR, Riordan JT, et al.: Isolation from hum an sera in Egypt of a virus apparently identical to West Nile virus. Proc Soc Exp Biol M ed 1951, 77:661–665.
Marberg K, Goldblum N, Sterk VV, Jasinska-Klingberg W, Klingberg MA: The natural history of West Nile fever: clinical observations during an epidem ic in Israel. Am J Hyg 1956, 64:259–269.
Pruzanski W, Altman R: Encephalitis due to West Nile fever virus. World Neurol 1962, 3:524–527.
Southam CM, Moore AE: Induced virus infections in m an by the Egypt isolates of West Nile virus. Am J Trop Med Hyg 1954, 3:19–50.
George S, Gourie-Devi M, Rao JA, Prasad SR, Pavri KM: Isolation of West Nile virus from the brains of children who had died of encephalitis. Bull W orld Health Org 1984, 62:879–882.
Hubalek Z, Halouzka J: West Nile fever—a reem erging m osquito-borne viral disease in Europe. Emerg Infect Dis 1999, 5:643–650.
Le Guenno B, Bougermouth A, Azzam T, Bouakaz R: West Nile: a deadly virus? Lancet 1996, 348:1315.
Tsai TF, Popovici F, Cernescu C, Campbell GL, Nedelcu NI: West Nile encephalitis epidem ic in southeastern Rom ania. Lancet 1998, 352:767–771.
Ceianu CS, Ungureanu A, Nicolescu G, et al.: West Nile virus surveillance in Rom ania. Viral Immunol 2001, 14:251–262.
Platonov AE, Shipukin GA, Shipulina OY, et al.: Outbreak of West Nile virus infection, Volgograd region, Russia, 1999. Em erg Infect Dis 2001, 7:128–132.
Weinberger M, Pitilik SD, Gandacu D, et al.: West Nile fever outbreak, Israel, 2000: epidem iological aspects. Emerg Infect Dis 2001, 7:686–691.
Chowers MY, Lang R, Nassar F, et al.: Clinical characteristics of West Nile fever outbreaks, Israel, 2000. Emerg Infect Dis 2001, 7:675–678.
Fine A, Layton M: Lessons from the West Nile viral encephalitis outbreak in New York City, 1999: im plications for bioterrorism preparedness. Clin Infect Dis 2001, 32:277–282. This is a personal, first-hand account of the discovery and response to the 1999 New York City outbreak.
Nash D, Mostashari F, Fine A, et al.: The outbreak of West Nile virus infection in the New York City area in 1999. N Engl J M ed 2001, 344:1807–1814. Am ore detailed analysis of the 1999 New York City outbreak, including diagnostic criteria, clinical features, and pathologic findings.
Steele KE, Linn MJ, Schoepp RJ, et al.: Pathology of fatal West Nile virus infections in native and exotic birds during the 1999 outbreak in New York City. Vet Pathol 2000, 37:208–228.
Centers for Disease Control and Prevention: O utbreak of West Nile-like viral encephalitis-New York, 1999. M M W R 1999, 48:845–849.
Gubler DJ, Campbell GL, Nasci R, et al.: West Nile virus in the United States: guidelines for detection, prevention, and control. Viral Immunol 2000, 13:469–475. The surveillance, laboratory diagnosis, control, and research priorities are review ed.
Mostashari F, Bunning ML, Kitsutani PT, et al.: Epidemic West Nile encephalitis, New York, 1999: results of a householdbased seroepidem iological survey. Lancet 2001, 358:261–264.
Bunning ML, Bowen RA, Cropp B, et al.: Experim ental infection of horses with West Nile virus. Em erg Infect Dis 2002, 8:380–386.
Nasci RS, Savage HM, White DJ, et al.: West Nile virus in overwintering Culex m osquitoes, New York City, 2000. Em erg Infect Dis 2001, 7:742–744.
Garmendia AE, Van Kruiningen HJ, French RA, et al.: Recovery and identification of West Nile virus from a hawk in winter. J Clin Microbiol 2000, 38:3110–3111.
Centers for Disease Control and Prevention: Update: West Nile virus activity—Eastern United States, 2000 M M W R 2000, 49:1044–1047.
Johnson RT: West Nile virus in the United States and abroad. Curr Top Infect Dis 2002, 22:52–60.
Johnson RT: Viral Infections of the Nervous System, edn 2. Philadelphia: Lippincott-Raven; 1998.
Taylor RM: Epidem iology. In Yellow Fever. Edited by Strode G. New York: McGraw-Hill; 1951:427–538.
Ebel GD, Dupuis AP, Ngo K, et al.: Partial genetic characterization of West Nile virus strains, New York State, 2000. Emerg Infect Dis 2001, 7:650–653.
Rappole JH, Derrickson SR, Hubalek Z: M igratory birds and spread of West Nile virus in the western hem isphere. Em erg Infect Dis 2000, 6:319–328.
Lanciotti RS, Roehrig JT, Deubel V, et al.: O rigin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science 1999, 286:2333–2337. The sequence analysis of West Nile virus isolates in birds, mosquitoes, and humans in the United States indicates a com m on origin. The North American strain is most closely related to an Israel isolate found in 1998.
Ahmed S, Libman R, Wesson K, Ahmed F, Einberg K: Guillain-Barre syndrom e: an unusual presentation of West Nile virus infection. Neurology 2000, 55:144–146.
Asnis DS, Conetta R, Teixeira AA, Waldman G, Sampson BA: The West Nile virus outbreak of 1999 in New York: the Flushing Hospital experience. Clin Infect Dis 2000, 30:413–418.
Sampson BA, Ambrosi C, Charlot A, et al.: The pathology of hum an West Nile virus infection. Hum Pathol 2000, 31:527–531.
Meek J: West Nile virus in the United States. Curr Opin Pediatr 2002, 14:72–77.
McIntosh BM, McGillivray GM, Dickinson DB: Illness caused by Sindbis and West Nile viruses in South Africa. South Afr M ed J 1964, 38:291–294.
Georges AJ, Lesbordes JL, Georges-Courbot MC, Meunier DM, Gonzalez JP: Fatal hepatitis from West Nile virus. Ann Inst Pasteur/ Virol 1987, 138:237–244.
Briese T, Glass WG, Lipkin WI: Detection of West Nile virus sequences in cerebrospinal fluid. Lancet 2000, 355:1614–1615.
Jordan I, Brises T, Fischer N, Lau JY, Lipkin WI. Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells. J Infect Dis 2000, 182:1214–1217.
Hoke CH, Vaugh DW, Nisalak A, et al.: The effect of high-dose dexam ethasone on the outcom e of acute encephalitis due to Japanese encephalitis virus. J Infect Dis 1992, 165:631–637.
Davis BS, Chang GJ, Cropp B, et al.: West Nile virus recom binant DNA vaccine protects m ouse and horse from virus challenge and express in vitro a noninfectious recom binant antigen that can be used in enzyme-linked immunosorbent assays. J Virol 2001, 75:4040–4047.
Monath TP: Prospects for development of a vacine against the West Nile virus. Ann NY Acad Sci 2001, 951:1–12. Strategies for vaccine development are concisely presented. The novel technology for developing a chimeric vacine uses yellow fever 17D as a live vector for envelope genes of West Nile virus.
Pletnev AG, Putnak R, Speicher J, Wagar EJ, Vaughn DW: West Nile virus/dengue type 4 virus chim eras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy. Proc Natl Acad Sci U S A 2002, 99:3036–3041.
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Johnson, R.T., Irani, D.N. West Nile virus encephalitis in the United States. Curr Neurol Neurosci Rep 2, 496–500 (2002). https://doi.org/10.1007/s11910-002-0035-0
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DOI: https://doi.org/10.1007/s11910-002-0035-0