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A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk

  • Hypertension and Obesity (E Reisin, Section Editor)
  • Published:
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Abstract

Perivascular adipose tissue (PVAT) is now recognized as an important paracrine organ influencing the homeostasis of the vessel wall, regional blood flow and peripheral arterial resistance. There is remarkable phenotypic variability and plasticity of PVAT among various vascular beds, exhibiting phenotypes from white to brown and beige adipocytes. PVAT dysfunction is characterized by disturbed secretion of various adipokines, which, together with endothelial dysfunction, contribute to hypertension and cardiovascular disease (CVD). This brief review describes our current knowledge on PVAT in health and cardiovascular disease, with a special focus on different phenotypes and signaling pathways in adipocytes of PVAT associated with hypertension, obesity and cardiovascular disorders.

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Acknowledgments

The Deutsche Forschungsgemeinschaft (DFG) (MG), Deutsche Akademische Austauschdienst (DAAD) (MG) and Shanghai Tongji Hospital (XL) are supporting our studies. We thank Mario Kassmann and Dmitry Tsvetkov for critical reading and helpful comments on the manuscript.

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  1. Experimental and Clinical Research Center (ECRC) – a joint cooperation between the Charité-University Medicine Berlin and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany

    Xiaoming Lian & Maik Gollasch

  2. Medical Clinic for Nephrology and Internal Intensive Care, Charité Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany

    Maik Gollasch

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  1. Xiaoming Lian
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This article is part of the Topical Collection on Hypertension and Obesity

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Lian, X., Gollasch, M. A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk. Curr Hypertens Rep 18, 82 (2016). https://doi.org/10.1007/s11906-016-0692-z

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