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Corin in Natriuretic Peptide Processing and Hypertension

  • Mediators, Mechanisms, and Pathways in Tissue Injury (T Fujita, Section Editor)
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Abstract

Corin is a serine protease originally isolated from the heart. Functional studies show that corin is the long-sought enzyme responsible for activating cardiac natriuretic peptides. In mice, lack of corin prevents natriuretic peptide processing, causing salt-sensitive hypertension. In humans, corin variants and mutations that reduce corin activity have been identified in patients with hypertension and heart failure. Decreased plasma levels of corin antigen and activity have been reported in patients with heart failure and coronary artery disease. Low levels of urinary corin also have been found in patients with chronic kidney disease. Most recent studies show that corin also acts in the uterus to promote spiral artery remodeling and prevent pregnancy-induced hypertension. Here, we review the role of corin in natriuretic peptide processing and cardiovascular diseases such as hypertension, heart disease, pre-eclampsia, and chronic kidney disease.

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Acknowledgments

We would like to thank our co-workers, past and present, who contributed to corin studies. This work was supported in part by NIH grants R01 HL089298 and HD064634, and grants from the National Natural Science Foundation of China (31070716, 81170247 and 31161130356) and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.

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Yiqing Zhou and Qingyu Wu declare that they have no conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou, China

    Yiqing Zhou & Qingyu Wu

  2. Departments of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Qingyu Wu

  3. Molecular Cardiology, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH, 44195, USA

    Qingyu Wu

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  1. Yiqing Zhou
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Correspondence to Qingyu Wu.

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This article is part of the Topical Collection on Mediators, Mechanisms, and Pathways in Tissue Injury

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Zhou, Y., Wu, Q. Corin in Natriuretic Peptide Processing and Hypertension. Curr Hypertens Rep 16, 415 (2014). https://doi.org/10.1007/s11906-013-0415-7

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