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Pathophysiology of obesity hypertension

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Abstract

Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with weight gain. Activation of the renin-angiotensin and sympathetic nervous systems and physical compression of the kidneys appear to contribute to obesity-induced increases in sodium reabsorption and hypertension.

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  1. Department of Physiology & Biophysics, University of Mississippi Medical Center, 2500 North State Street, 39216-4505, Jackson, MS, USA

    John E. Hall PhD

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  1. John E. Hall PhD
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Hall, J.E. Pathophysiology of obesity hypertension. Current Science Inc 2, 139–147 (2000). https://doi.org/10.1007/s11906-000-0073-4

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  • DOI: https://doi.org/10.1007/s11906-000-0073-4

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