Skip to main content
SpringerLink
Log in

Endothelial lipase and cholesterol metabolism

  • Published:
Current Atherosclerosis Reports Aims and scope Submit manuscript

Abstract

Endothelial lipase (EL), a new member of the lipase gene family, was recently cloned and has a significant role in plasma high-density lipoprotein levels (HDL). EL has a highly similar molecular homology to lipoprotein lipase and hepatic lipase. It is synthesized by endothelial cells and functions at the cell surface. EL primarily has phospholipase AI activity. Animals that overexpress EL showed decreased HDL cholesterol levels and those that lack EL show elevated levels of HDL cholesterol. The expression is highly regulated by cytokines and physical forces. These data suggest that EL may play a significant role in atherosclerosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Castelli WP: Cholesterol and lipids in the risk of coronary artery disease-the Framingham Heart Study. Can J Cardiol 1988, 4(suppl A):5A-10A.

    PubMed  Google Scholar 

  2. Hirata K, Dichek HL, Cioffi JA, et al.: Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem 1999, 274:14170–14175.

    Article  PubMed  CAS  Google Scholar 

  3. Jaye M, Lynch KJ, Krawiec J, et al.: A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet 1999, 21:424–428.

    Article  PubMed  CAS  Google Scholar 

  4. Strauss JG, Zimmermann R, Hrzenjak A, et al.: Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymatic activity. Biochem J 2002, 15:368:69–79.

    Article  Google Scholar 

  5. Choi S, Hirata K, Ishida T, et al.: Endothelial lipase: a new lipase on the block. J Lipid Res 2002, 43:1763–1769.

    Article  PubMed  CAS  Google Scholar 

  6. McCoy MG, Sun G, Marchadier D, et al.: Characterization of the lipolytic activity of endothelial lipase. J Lipid Res 2002, 43:921–929.

    PubMed  CAS  Google Scholar 

  7. Rader DJ, Jaye M: Endothelial lipase: a new member of the triglyceride lipase gene family. Curr Opin Lipidol 2000, 11:141–147.

    Article  PubMed  CAS  Google Scholar 

  8. Weijun J, Gwo-Shing S, Dawn M, et al.: Endothelial cells secrete triglyceride lipase and phospholipase activities in response to cytokines as a result of endothelial lipase. Circ Res 2003, 92:1–9.

    Article  Google Scholar 

  9. Tsutsumi K, Inoue Y, Shima A, et al.: The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. J Clin Invest 1993, 92:411–417.

    Article  PubMed  CAS  Google Scholar 

  10. Mezdour H, Jones R, Dengremont C, et al.: Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 1997, 272:13570–13575.

    Article  PubMed  CAS  Google Scholar 

  11. Ma K, Cilingiroglu M, Otvos JD, et al.: Endothelial lipase is a major genetic determinant for high- density lipoprotein concentration, structure and metabolism. Proc Natl Acad Sci U S A 2003, 100:2748–2753.

    Article  PubMed  CAS  Google Scholar 

  12. Tatsuro I, Sungshin C, Ramendra KK, et al.: Endothelial lipase is a major determinant of HDL level. J Clin Invest 2003, 111:347–355.

    Article  CAS  Google Scholar 

  13. Weijun J, John SM, Uli B, et al.: Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J Clin Invest 2003, 111:357–362.

    Article  CAS  Google Scholar 

  14. deLemos AS, Wolfe ML, Long CJ, et al.: Identification of genetic variants in endothelial lipase in persons with elevated high-density lipoprotein cholesterol. Circulation 2002, 106:1321–1326.

    Article  PubMed  CAS  Google Scholar 

  15. West MS, Herd AJ, Ballantyne CM, et al.: Lipoprotein and Coronary Atherosclerosis Study (LCAS). Control Clin Trials 1996, 17:550–583.

    Article  PubMed  CAS  Google Scholar 

  16. Shimada M, Ishibashi S, Inaba T, et al.: Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci U S A 1996, 93:7242–7246.

    Article  PubMed  CAS  Google Scholar 

  17. Yagyu H, Ishibashi S, Chen Z, et al.: Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 1999, 40:1677–1685.

    PubMed  CAS  Google Scholar 

  18. Rutledge JC, Woo MM, Rezai AA, et al.: Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial cell permeability by formation of lipolysis products. Circ Res 1997, 80:819–828.

    PubMed  CAS  Google Scholar 

  19. Cohen JC, Vega GL, Grundy SM, et al.: Hepatic lipase: new insights from genetic and metabolic studies. Curr Opin Lipidol 1999, 10:259–267.

    Article  PubMed  CAS  Google Scholar 

  20. Ordovas JM: Endothelial lipase: a new member of the family. Nutr Rev 1999, 57:284–287.

    Article  PubMed  CAS  Google Scholar 

  21. Ross R: Atherosclerosis-an inflammatory disease. N Engl J Med 1999, 340:115–126.

    Article  PubMed  CAS  Google Scholar 

  22. Kojima Y, Shimokava Y, Rikitake Y, et al.: Inflammatory response induces the expression of endothelial cell-derived lipase [abstract]. Presented at AHA Scientific Sessions, Anaheim, CA, 2002.

  23. Zhang, SH, RL Reddick, Piedrathita JA, et al.: Sponteneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992, 258:468–471.

    Article  PubMed  CAS  Google Scholar 

  24. Grosskopf I, David C, Hirata K, et al.: Presented at AHA Scientific Sessions, Anaheim, CA, 2002.

  25. Cohen JC: Endothelial lipase: direct evidence for a role in HDL metabolism. J Clin Invest 2003, 111:318–321.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Cardiology and Atherosclerosis, Baylor College of Medicine, One Baylor Plaza, Jewish Building 519-D, 77030, Houston, TX, USA

    Mehmet Cilingiroglu MD & Christie Ballantyne MD

Authors
  1. Mehmet Cilingiroglu MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christie Ballantyne MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cilingiroglu, M., Ballantyne, C. Endothelial lipase and cholesterol metabolism. Curr Atheroscler Rep 6, 126–130 (2004). https://doi.org/10.1007/s11883-004-0101-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11883-004-0101-y

Keywords

Search

Navigation