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BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?

  • Anaphylaxis and Drug Allergy (David A. Khan & Mariana Castells, Section Editors)
  • Published:
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Abstract

Purpose of Review

The aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives.

Recent Findings

Basophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions.

Summary

Currently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests.

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Authors and Affiliations

  1. Clinical Immunology and Allergy Division, University of São Paulo, R. Prof. Artur Ramos 178 ap.211A, Jd. América, São Paulo, SP, CEP: 01454-904, Brazil

    Lucila Campos, Violeta Régnier Galvão, Jorge Kalil & Pedro Giavina-Bianchi

  2. Harvard medical School, Boston, MA, USA

    Mariana Castells

  3. Adverse Drug Reactions and Desesitization Program, Brigham and Women’s Hospital, Jimmy Fund Way, Smith Building, Boston, MA, USA

    Mariana Castells

  4. Allergy and Immunology Training Program, department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Mariana Castells

  5. Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA

    Mariana Castells

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  1. Lucila Campos
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  2. Violeta Régnier Galvão
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  3. Jorge Kalil
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  4. Mariana Castells
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  5. Pedro Giavina-Bianchi
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Campos, L., Galvão, V.R., Kalil, J. et al. BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?. Curr Allergy Asthma Rep 19, 20 (2019). https://doi.org/10.1007/s11882-019-0852-8

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