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Enhancement of Biocompatibility of Fish Scale-Based Hydroxyapatite-Infused Fibrous Scaffolds by Low-Temperature Plasma

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Abstract

Owing to its excellent ability to enhance the cell growth and proliferation, hydroxyapatite (HAp) has received tremendous attention as a highly valuable biomaterials. Byproducts from the marine environment, especially fish scales, have proved to be a vital source for HAp. Nevertheless, HAp still has a profound influence on the matrices designed for biomedical applications. In this study, fish scale-derived nano-hydroxyapatite (n-HAp) = infused non-woven polycaprolactone (PCL) fibrous scaffolds are developed byforce spinning. The surface properties of the nanofibrous scaffolds are modified by oxygen plasma treatment, and their influence on n-HAP-infused PCL scaffolds is investigated. Plasma treatment is favorable for 2 wt.% and 3 wt.% scaffolds with a high O/C ratio and improving C=O content, and are found to have high cell growth. The 3 wt.% scaffolds have high crystallinity which is twice the crystallinity of neat fibers. The plasma treated 2 wt.% and 3 wt.% scaffolds were found to have high cell growth almost twice that of neat scaffolds, and these observations complied with the results from x-ray photoelectron spectroscopy (XPS). The plasma treatment enhances the functional properties and biocompatibility of fibrous scaffolds containing 2 and 3 wt.% n-HAP.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors acknowledge financial support from NSF-CREST #1735971, NSF-EPSCoR # 1655280, NSF-RISE # 1459007, NSF-MRI, #1531934 and grant #G12MD007585. The authors also acknowledge Dr. Paul Baker from University of Alabama in Birmingham for his support in XPS studies.

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Authors and Affiliations

  1. Department of Materials Science Engineering, Tuskegee University, Tuskegee, AL, 36088, USA

    Deepa Kodali, Zaheeruddin Mohammed, Shaik Jeelani & Vijaya K. Rangari

  2. Department of Mechanical Engineering, Christian Brothers University, Memphis, TN, 38104, USA

    Deepa Kodali

  3. Department of Biomedical Sciences, Tuskegee University, Tuskegee, AL, 36088, USA

    Dilip Reddy Gunturu & Temesgen Samuel

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Kodali, D., Mohammed, Z., Gunturu, D.R. et al. Enhancement of Biocompatibility of Fish Scale-Based Hydroxyapatite-Infused Fibrous Scaffolds by Low-Temperature Plasma. JOM 75, 2174–2186 (2023). https://doi.org/10.1007/s11837-023-05750-5

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