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Association between KITLG Gene Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-analysis

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Summary

It has been reported that c-KIT ligand (KITLG) gene polymorphisms may be associated with testicular germ cell tumors (TGCT). Owing to mixed and inconclusive results, we conducted a systematic review and meta-analysis to summarize and clarify this association. A systematic search of studies on the association between KITLG gene polymorphisms and TGCT susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size. Six articles were included in our systematic review and meta-analysis. Compared with adenine (A), KITLG rs995030 guanine (G) might be associated with increased risk of TGCT. There are insufficient data to fully confirm the association between KITLG rs4474514 and TGCT susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.

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Authors and Affiliations

  1. Department of Urology Surgery, Center of Diagnosis and Treatment of Urinary System Diseases; the Key Laboratory of Urinary Tract Tumors and Calculi of Xiamen City, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, China

    Jia-xuan Qin, Yu-feng Yang, Jin-chun Xing & Xuan Zhuang

  2. The First Clinical Medical School of Fujian Medical University, Xiamen, 361003, China

    Zong-long Cai

Authors
  1. Jia-xuan Qin
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  2. Zong-long Cai
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  3. Yu-feng Yang
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  4. Jin-chun Xing
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  5. Xuan Zhuang
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Corresponding author

Correspondence to Xuan Zhuang.

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Conflict of Interest Statement

All authors declare that they have no conflict of interest.

This study was supported by grants from the First Affiliated Hospital of Xiamen University for Young Scholars (No. XYY2016011) and Fujian Provincial Department of Science and Technology (No. 2016D009).

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Qin, Jx., Cai, Zl., Yang, Yf. et al. Association between KITLG Gene Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-analysis. CURR MED SCI 39, 702–706 (2019). https://doi.org/10.1007/s11596-019-2095-2

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  • DOI: https://doi.org/10.1007/s11596-019-2095-2

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