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Novel nanostructured electrochemical sensor for voltammetric determination of N-acetylcysteine in the presence of high concentrations of tryptophan

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Abstract

A carbon paste electrode chemically modified with multiwall nanotubes and ethynylferrocene (ETFc) was used as a selective and sensitive electrochemical sensor for the determination of minor amounts of N-acetylcysteine (N-AC) in the presence of a high concentration of tryptophan (Trp). Square wave voltammetry (SWV) of N-AC at the modified electrode exhibited linear dynamic range with a detection limit (3 s) of 0.08 μmol L−1. The separations of anodic peak potentials of N-AC and Trp reached 400 mV using SWV. With good selectivity and sensitivity, the present method provides a simple method for selective detection of N-AC in real samples such as drug and urine.

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Acknowledgments

The authors gratefully acknowledge the research council of Islamic Azad University, Falavarjan Branch and the National Foundation for Iranian Elites for their support of this work.

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Correspondence to Masoud Fouladgar.

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Fouladgar, M., Karimi-Maleh, H. & Hosseinzadeh, R. Novel nanostructured electrochemical sensor for voltammetric determination of N-acetylcysteine in the presence of high concentrations of tryptophan. Ionics 19, 665–672 (2013). https://doi.org/10.1007/s11581-012-0794-9

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