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Palladium-catalyzed R2(O)P-directed C(sp2)-H activation

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Abstract

In recent years, transition-metal-catalyzed inert C-H bond activation has developed rapidly and is a powerful protocol for the construction of new C-C or C-X bonds and the introduction of new functional groups. Our group has also developed a series of R2(O)P-directed Pd-catalyzed C-H functionalizations involving olefination, hydroxylation, acetoxylation, arylation, and acylation through an uncommon seven-membered cyclo-palladium pretransition state. Unlike previously used directing groups, the R2(O)P group acts as a directing group and is also involved in the construction of P,-hetero-ligands.

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Authors and Affiliations

  1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China

    Hongyu Zhang & Shangdong Yang

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  1. Hongyu Zhang
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  2. Shangdong Yang
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Correspondence to Shangdong Yang.

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Zhang, H., Yang, S. Palladium-catalyzed R2(O)P-directed C(sp2)-H activation. Sci. China Chem. 58, 1280–1285 (2015). https://doi.org/10.1007/s11426-015-5382-1

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