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Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain

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Abstract

Chlorogenic acid (CGA) is a natural organic phenolic compound that is found in many plants, fruits and vegetables. CGA has beneficial bioactivities and strong therapeutic effects in inflammatory processes. CGA-rich fractions have analgesic activity but CGA has not been tested previously in neuropathic pain, which results from tissue damage, inflammation or injury of the nervous system. Chronic constrictive nerve injury (CCI) is a peripheral neuropathic pain model which initiates an inflammatory cascade. We aimed to determine possible antihyperalgesic effects of CGA in neuropathic pain. Our study showed for the first time that CGA [50, 100 and 200 mg/kg; intraperitoneally (i.p.)] produced significant dose- and time-dependent antihyperalgesic activity in CCI-induced neuropathic pain. In addition, chronic administration of CGA (100 mg/kg/day; i.p. for 14 days) prevented the development of mechanical hyperalgesia and attenuated CCI-induced histopathological changes. On the other hand, CGA (200 mg/kg) did not affect falling latencies of rats in the rota rod test. Hence, CGA might represent a novel potential therapeutic option for the management of neuropathic pain.

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Acknowledgments

The authors give special thanks to Dr. Mehmet Cansev for his contribution to the English editing of the manuscript.

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Authors and Affiliations

  1. Experimental Animals Breeding and Research Center, Faculty of Medicine, Uludag University, Bursa, Turkey

    Deniz Bagdas

  2. Department of Biology, Faculty of Science and Arts, Uludag University, Bursa, Turkey

    Nilufer Cinkilic

  3. Department of Pharmacology, Faculty of Medicine, Uludag University, Bursa, Turkey

    Hasret Yucel Ozboluk & Mine Sibel Gurun

  4. Department of Pathology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey

    Musa Ozgur Ozyigit

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  1. Deniz Bagdas
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  2. Nilufer Cinkilic
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  3. Hasret Yucel Ozboluk
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  4. Musa Ozgur Ozyigit
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  5. Mine Sibel Gurun
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Correspondence to Deniz Bagdas.

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Bagdas, D., Cinkilic, N., Ozboluk, H.Y. et al. Antihyperalgesic activity of chlorogenic acid in experimental neuropathic pain. J Nat Med 67, 698–704 (2013). https://doi.org/10.1007/s11418-012-0726-z

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  • DOI: https://doi.org/10.1007/s11418-012-0726-z

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