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Evening and morning exhaled volatile compound patterns are different in obstructive sleep apnoea assessed with electronic nose

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Abstract

Purpose

Electronic noses represent a technique for the measurement of exhaled breath volatile compound pattern which can discriminate patients with obstructive sleep apnoea (OSA) from control subjects. Although overnight changes in circulating biomarkers were reported, this effect on the exhaled volatile compound pattern has not been studied before. We aimed to compare breath patterns in the evening and in the morning in patients with OSA and to study the ability of the electronic nose to distinguish patients from controls based on these exhaled volatile patterns.

Methods

Exhaled breath volatile compound pattern was measured before and after night in 26 patients with suspected sleep-disordered breathing (53 ± 15 years) who underwent polysomnography and in ten control subjects (37 ± 15 years), by whom sleep-disordered breathing was excluded with a home apnoea screening device. Breath measurements were also performed in the morning in 26 healthy, non-smoking age-matched controls (48 ± 10 years) with no complaints about disturbed sleep. Exhaled volatile compound pattern was processed with a Cyranose 320 electronic nose, and principal component analysis was used for statistical analysis.

Results

Exhaled volatile compound patterns recorded in the evening and in the morning were different in patients with OSA (p = 0.01) but not in non-OSA habitual snorers (p = 0.49) or in control subjects (p = 0.23). The electronic nose distinguished patients with OSA from control subjects based on the breath samples collected in the morning (p < 0.001, classification accuracy 77 %) but not in the evening (p > 0.05).

Conclusions

Evening and morning exhaled volatile compound patterns are different in OSA. This might affect the ability of electronic noses to identify this disorder. Overnight alterations in volatile substances need to be taken into account during exhaled breath measurements in OSA.

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Acknowledgments

The study was supported by a Hungarian Scientific Research Fund (OTKA 68808) and Hungarian Respiratory Society research grant (to Andras Bikov). The authors are grateful to Monika Banlaky for assistance in sample collection and to Anna Grove for English corrections.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary

    Laszlo Kunos, Andras Bikov, Zsofia Lazar, Beata Zita Korosi, Gyorgy Losonczy & Ildiko Horvath

  2. Department of Otorhinolaryngology and Bronchology, Heim Pál Children’s Hospital, 86 Ulloi Street, Budapest, 1089, Hungary

    Palma Benedek

Authors
  1. Laszlo Kunos
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  2. Andras Bikov
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  3. Zsofia Lazar
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  4. Beata Zita Korosi
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  5. Palma Benedek
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  6. Gyorgy Losonczy
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  7. Ildiko Horvath
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Correspondence to Andras Bikov.

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Kunos, L., Bikov, A., Lazar, Z. et al. Evening and morning exhaled volatile compound patterns are different in obstructive sleep apnoea assessed with electronic nose. Sleep Breath 19, 247–253 (2015). https://doi.org/10.1007/s11325-014-1003-z

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  • DOI: https://doi.org/10.1007/s11325-014-1003-z

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