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Acute sleep deprivation in healthy adults is associated with a reduction in left atrial early diastolic strain rate

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Abstract

Background

Sleep deprivation (SD) is known to be associated with adverse cardiovascular events. Strain and strain rate measure the local deformation of the myocardium and have been used to evaluate atrial phasic function in various disease states. The aim of the study was to investigate whether strain rate imaging enables the identification of left atrial dysfunction in otherwise healthy young adults with acute SD which has not been studied previously.

Methods

Adequate echocardiographic images of 27 healthy volunteers were obtained both after a night with regular sleep and after a night with SD. Tissue Doppler-derived strain and strain rate were measured from the apical four- and two-chamber views of the left atrium, and global values were calculated as the mean of all segments. Measurements included peak systolic strain, systolic strain rate (S-Sr), early diastolic (E-Sr) and late diastolic (A-Sr) strain rate. Phasic left atrial (LA) volumes and fractions were also calculated.

Results

There was no significant difference in the traditional parameters of atrial function and LA volumes. Subjects had similar S-Sr, A-Sr and global atrial strain values after the night of sleep debt when compared after regular sleep, whereas they had significantly reduced E-Sr values (mean (SD) 3.2 (0.7) s−1 vs 3.7 (0.6) s−1, p < 0.001). Moreover, global E-Sr showed a significant correlation with sleep time (r = 0.554, p < 0.001).

Conclusion

Acute SD in healthy adults is associated with a reduction in LA early diastolic strain rate in the absence of geometric alterations or functional impairment of the left atrium, raising the possibility that chronic SD may more profoundly affect LA function and thereby promote the occurrence of atrial fibrillation.

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Conflict of interest

The authors certify that there is no conflict of interest with any financial organization regarding the material discussed in this article.

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Authors and Affiliations

  1. Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Heart Education and Research Hospital, Istanbul, Turkey

    Göksel Açar, Mustafa Akçakoyun, Mustafa Bulut, Elnur Alizade, Birol Özkan, Mehmet Vefik Yazicioğlu, Gökhan Alici, Ramazan Kargin & Ali Metin Esen

  2. Department of Cardiology, Marmara University, Istanbul, Turkey

    Ibrahim Sari

  3. Department of Cardiology, Ordu State Hospital, Ordu, Turkey

    Anil Avci

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  1. Göksel Açar
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  2. Mustafa Akçakoyun
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Correspondence to Ibrahim Sari.

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Açar, G., Akçakoyun, M., Sari, I. et al. Acute sleep deprivation in healthy adults is associated with a reduction in left atrial early diastolic strain rate. Sleep Breath 17, 975–983 (2013). https://doi.org/10.1007/s11325-012-0786-z

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  • DOI: https://doi.org/10.1007/s11325-012-0786-z

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