Abstract
Background
Metabolic disorders are one of the etiologic factors in renal stone formation. The aim of present study was to evaluate prevalence of metabolic disorders in patients with renal stone.
Methods
From 572 patients referring to our urologic clinics, 376 patients participated in the study. Patients were divided to first time stone former (group A) and recurrent renal stone (group B). Twenty-four hour urine specimens were obtained for urinary calcium, oxalate, magnesium, citrate, uric acid, phosphor and 24-h urine volume. Venous blood samples were obtained evaluating serum phosphate, uric acid, and calcium. The prevalence of each metabolic disorder was detected, and two groups were compared regarding metabolic disorders.
Results
The prevalence of renal stone in male patients was 63.04% versus 36.96% in female patients (P < 0.05). The most common abnormality observed in patients was low 24-h urine volume (58.24%) followed by hypercalciuria (17.18%) and hyperuricosuria (15.15%). Hyperuricemia was found in 6 first time stone former patients and 14 patients with recurrent renal stone (P = 0.04). There was no statistically significant difference between group A and B in other metabolic abnormalities (P > 0.05).
Conclusion
Low 24-h urine volume was the most common abnormalities in patients with nephrolithiasis in our region. Metabolic evaluation must be performed in all patients with renal stone even those with first time stone formation.
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References
Moe OW (2006) Kidney stones: pathophysiology and medical management. Lancet 367:333–344
Pak CYC, Resnick MI, Preminger GM (1997) Ethnic and geographic diversity of stone disease. Urology 50:504–507
Evan AP, Bledsoe SB, Smith SB, Bushinsky DA (2004) Calcium oxalate crystal localization and osteopontin immunostaining in genetic hypercalciuric stone-forming rats. Kidney Int 65:154–161
Schor Ita Pfeferman Heilberg Nestor (2006) Renal stone disease: causes, evaluation and medical treatment. Arq Bras Endocrinol Metab 50:823–831
Bushinsky DA (1998) Nephrolithiasis. J Am Soc Nephrol 9:917–924
Coe FL, Parks JH, Asplin JR (1992) The pathogenesis and treatment of kidney stones. N Engl J Med 327:1141–1152
Coe FL, Parks JH (1997) New insights into the pathophysiology and treatment of nephrolithiasis: new research venues. J Bone Miner Res 12:522–533
Borghi L, Meschi T, Amato F, Briganti A, Novarini A, Giannini A (1996) Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol 155:839–843
Coe FL, Parks JH (1998) Nephrolithiasis: pathogenesis and treatment, 2nd edn. Year Book Medical Publishers, Chicago, pp 109–110
Albright F, Henneman P, Benedict PH, Forbes AP (1953) Idiopathic hypercalciuria: a preliminary report. Proc Roy Soc Med 46:1077–1081
Yagisawa T, Chandhoke PS, Fan J (1998) Metabolic risk factors in patients with first-time and recurrent stone formations as determined by comprehensive metabolic evaluation. Urology 52:750–755
Leslie SW (1989) Outpatient metabolic evaluation of patients with recurrent kidney stones. Ohio Med 85:292–294
Auge BK, Maloney ME, Mathias BJ, Pietrow PK, Preminger GM (2006) Metabolic abnormalities associated with calyceal diverticular stones. BJU Int 97:1053–1056
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Hosseini, M.M., Eshraghian, A., Dehghanian, I. et al. Metabolic abnormalities in patients with nephrolithiasis: comparison of first-episode with recurrent cases in Southern Iran. Int Urol Nephrol 42, 127–131 (2010). https://doi.org/10.1007/s11255-009-9599-9
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DOI: https://doi.org/10.1007/s11255-009-9599-9