Skip to main content

Advertisement

SpringerLink
Log in

Global developments of genome editing in agriculture

  • Proceedings Paper
  • Published:
Transgenic Research Aims and scope Submit manuscript

Abstract

Genome editing, particularly using of site-directed nucleases such as the CRISPR system, has spread rapidly through the biological sciences. Genome editing in crops could significantly speed up the progress of breeding programs. It could drive the development of traits in new crops and allow improvements in yield and pest resistance, adaptation to climate change, and industrial and pharmaceutical applications. However biofortification is a key challenge to satisfy nutritional needs in vitamins for developing countries and new consumer’s needs for developed countries. China and the USA lead scientific research in crop editing. Nigeria, being headquarters to numerous research consortia, is the most involved country in Africa. Genome editing in animals including pig, cattle, sheep, and carp, has not merely accelerated research but has made possible research that was previously unfeasible. It has been used to increase disease resistance, to make livestock better adapted to farming or environmental conditions, to increase fertility and growth, and to improve animal welfare. The USA, the UK and China are the most involved countries in animal genome editing. Global food production needs to increase as much as 70 per cent to support the growing population. Genome editing could contribute improving the efficiency of food distribution and reducing waste. Depending on the regulatory conditions, genome editing could open up the field to smaller companies and public labs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Notes

  1. https://www.ed.ac.uk/roslin/news-events/latest-news/gene-edited-pigs-resistant-billion-dollar-virus.

  2. https://curia.europa.eu/jcms/upload/docs/application/pdf/2018-07/cp180111en.pdf.

References

  • Bevacqua RJ, Fernandez-Martín R, Savy V, Canel NG, Gismondi MI, Kues WA, Carlson DF, Fahrenkrug SC, Niemann H, Taboga OA, Ferraris S, Salamone DF (2016) Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system. Theriogenology 86(8):1886–1896

    Article  CAS  PubMed  Google Scholar 

  • Burkard C, Lillico SG, Reid E, Jackson B, Mileham AJ, Ait-Ali T, Whitelaw CB, Archibald AL (2017) Precision engineering for PRRSV resistance in pigs: macrophages from genome edited pigs lacking CD163 SRCR1 domain are fully resistant to both PRRSV genotypes while maintaining biological function. PLoS Pathog 13(2):e1006206

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cardi T, Batelli G, Nicolia A (2017) Opportunities for genome editing in vegetable crops. Emerg Top Life Sci 1(2):193–207

    Article  Google Scholar 

  • Carlson DF, Lancto CA, Zang B, Kim ES, Walton M, Oldeschulte D, Seabury C, Sonstegard TS, Fahrenkrug SC (2016) Production of hornless dairy cattle from genome-edited cell lines. Nat Biotechnol 34(5):479–481

    Article  CAS  PubMed  Google Scholar 

  • Carroll D, Van Eenennaam AL, Taylor JF, Seger J, Voytas DF (2016) Regulate genome-edited products, not genome editing itself. Nat Biotechnol 34(5):477–479

    Article  CAS  PubMed  Google Scholar 

  • Cyranoski D (2015) Super-muscly pigs created by small genetic tweak. Nat 523:13–14

    Article  CAS  Google Scholar 

  • European Academies’ Science Advisory Council. Scientific Advice Mechanism (2012, 2015, 2017) New EASAC report on genome editing advises European policy-makers on how to approach groundbreaking research on plants, animals, microbes and humans. https://easac.eu/press-releases/details/new-easac-report-on-genome-editing-advises-european-policy-makers-on-how-to-approach-groundbreaking/

  • Fisher K (2016) Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing. Sci Rep 6:29081

    Article  CAS  Google Scholar 

  • Food and agriculture organization FAO (2009). Global agriculture towards 2050. High Level Expert Forum - How to Feed the World in 2050. http://www.fao.org/wsfs/forum2050/wsfs-background-documents/issues-briefs/en/

  • Houdebine LM (2018) Les nouveaux outils des biotechnologies animales. In: Regnault-Roger C, Houdebine LM, Ricroch A (Coordinateurs). Au-delà des OGM. Académie d’Agriculture de France et Presses des mines

  • Ishii T, Araki M (2016) Consumer acceptance of food crops developed by genome editing. Plant Cell Rep 35:1507–1518

    Article  CAS  PubMed  Google Scholar 

  • Jin YW, Zhao J (2017) Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. PNAS USA E9474–E9482 Published online 2017 www.pnas.org/cgi/doi/10.1073/pnas.1707853114

  • Lillico SG, Proudfoot C, Carlson DF, Stverakova D, Neil C, Blain C, King TJ, Ritchie WA, Tan W, Mileham AJ, McLaren DG, Fahrenkrug SC, Whitelaw CB (2013) Live pigs produced from genome edited zygotes. Sci Rep 3:2847

    Article  PubMed  PubMed Central  Google Scholar 

  • Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang GL, Luo Y, Qing Y, Jiao D, Zhao H, Zhou X, Wang S, Wei H, Güell M, Church GM, Yang L (2017) Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science 357(6357):1303–1307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pfeiffer M, Quétier F, Ricroch A (2018) Genome editing in plant breeding. In: Special issue ‘Transgenic plants and beyond’. In: Kuntz M (ed) Advances in botanical research. vol 86, pp 245–286

  • Proudfoot C, Burkard C (2017) Genome editing for disease resistance in livestock. Emerg Top Life Sci 1(2):209–219

    Article  Google Scholar 

  • Qiantao Z, Lin J, Huang J, Zhang H, Zhang R, Zhang X, Cao C, Hambly C, Qin G, Yao J, Song R, Jia Q, Wang X, Li Y, Zang N, Piao Z, Ye R, John R, Speakman R, Wang H, Zhou Q, Wang (2017)

  • Reardon S (2016) Welcome to the CRISPR zoo. Nat News 531(7593):160–163

    Article  CAS  Google Scholar 

  • Ricroch A (2018) Biotechnologies végétales: applications et perspectives agricoles. In: Regnault-Roger C, Houdebine LM and Ricroch A (Coordinateurs). Au-delà des OGM. Académie-d’Agriculture de France et Presses des mines

  • Ricroch A, Hénard MC (2015) Next biotech plants: new traits, crops, developers, and technologies for addressing global challenges. Crit Rev Biotechnol 1–16. http://informahealthcare.com/bty

  • Ricroch A, Harwood W, Svobodová Z, Sági L, Hundleby P, Badea E M, I Rosca, Cruz G, Salema Fevereiro MP, Marfà Riera V, Jansson S, Morandini P, Bojinov B, Cetiner S, Custers R, Schrader U, Jacobsen HJ, Martin-Laffon J, Boisron A Kuntz M (2015) Challenges Facing European Agriculture and Possible Biotechnological Solutions. Crit Rev Biotechnol 1–9 (early online: 1st July 2015). http://informahealthcare.com/doi/abs/10.3109/07388551.2015.1055707

  • Ricroch AE, Kuntz M, Ammann K (2016) Editing EU legislation to fit plant genome editing. EMBO Rep 17(10):1365–1369

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ricroch A, Clairand P, Harwood W (2017) Use of CRISPR systems in plant genome editing: towards new opportunities in agriculture. Emerg Top Life Sci 1(2):169–182

    Article  Google Scholar 

  • Ricroch A, Boussard JM, Dattée Y, Gallais A, Gate P, Houdebine LM, Kressmann G, Laquièze B, Gracien P, B Le Buanec, Mauchamp B, Richard- Molard M, Morot-Gaudry JF, Pelletier G, Pernollet JC, Planchenault D, Regnault-Roger C, Serpelloni M (2018). Green biotechnologies: a strategic issue for the future of the French seed industry. N3AF Academic Notes from the French Academy of Agriculture, 2, 1–19

  • Tan W, Carlson DF, Lancto CA, Garbe JR, Webster DA, Hackett PB, Fahrenkrug SC (2013) Efficient non meiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci USA 110:16526–16531

    Article  PubMed  Google Scholar 

  • United Nations, Department of Economic and Social Affairs, Population Division (2017). World Population Prospects: The 2017 Revision, Key Findings and Advance Tables. ESA/P/WP/248

  • US Department of Agriculture USDA (2018) Secretary Perdue Issues USDA Statement on Plant Breeding Innovation https://content.govdelivery.com/accounts/USDAAPHIS/bulletins/1e599ff

  • Van Eck J (2017) Gene editing in tomatoes. Emerg Top Life Sci 101(2):183–191

    Google Scholar 

  • Van Eenennaam AL (2017) Genetic modification of food animals. Curr Opin Biotechnol 44:27–34

    Article  CAS  PubMed  Google Scholar 

  • Whitworth KM, Rowland RR, Ewen CL, Trible BR, Kerrigan MA, Cino-Ozuna AG, Samuel MS, Lightner JE, McLaren DG, Mileham AJ, Wells KD, Prather RS (2016) Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus. Nat Biotechnol 34(1):20–22

    Article  CAS  PubMed  Google Scholar 

  • Zhao H, Wolt JD (2017) Risk associated with off-target plant genome editing and methods forits limitation. Emerg Topics Life Sci 1(2):231–240

    Article  Google Scholar 

Download references

Acknowledgements

The author would like to thank Dr John Davison for constructive criticism of the manuscript.

Author information

Authors and Affiliations

  1. Faculté Jean-Monnet, Université Paris-Sud, 54, Boulevard Desgranges, 92330, Sceaux, France

    Agnès Ricroch

  2. AgroParisTech, 16, Rue Claude-Bernard, 75231, Paris Cedex 05, France

    Agnès Ricroch

Authors
  1. Agnès Ricroch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Agnès Ricroch.

Ethics declarations

Conflict of interest

The author declares that there is no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Disclaimer: The opinions expressed and arguments employed in this paper are the sole responsibility of the author and do not necessarily reflect those of the OECD or of the governments of its Member countries.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ricroch, A. Global developments of genome editing in agriculture. Transgenic Res 28 (Suppl 2), 45–52 (2019). https://doi.org/10.1007/s11248-019-00133-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11248-019-00133-6

Keywords

Search

Navigation