Abstract
Theoretical study of several para-substituted N-nitrosoacetanilide biological molecules has been performed using density functional B3LYP method with 6-31G(d,p) basis set. Geometries obtained from DFT calculation were used to perform natural bond orbital analysis. The p characters of two nitrogen natural hybrid orbital (NHO) σ N3–N2 bond orbitals increase with increasing σ p values of the para substituent group on the benzene, which results in a lengthening of the N3–N2 bond. The p characters of oxygen NHO σ O1–N2 and nitrogen NHO σ O1–N2 bond orbitals decrease with increasing σ p values of the para substituent group on the benzene, which results in a shortening of the N2=O1 bond. It is also noted that decreased occupancy of the localized σ N3–N2 orbital in the idealized Lewis structure, or increased occupancy of \( \sigma_{\rm N3-N2}^{\ast}\) of the non-Lewis orbital, and their subsequent impact on molecular stability and geometry (bond lengths) are also related with the resulting p character of the corresponding nitrogen NHO of σ N3–N2 bond orbital.
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We thank the National Natural Science Foundation of China (No. 10774039) for the generous support.
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Li, XH., Zhang, RZ. & Zhang, XZ. Natural bond orbital analysis of some para-substituted N-nitrosoacetanilide biological molecules. Struct Chem 20, 1049–1054 (2009). https://doi.org/10.1007/s11224-009-9508-y
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DOI: https://doi.org/10.1007/s11224-009-9508-y