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Synthesis, crystal structure and antitumor activity of a dinuclear calcium complex based on 1,5-naphthalenedisulfonate and 2,2′-bipyridine ligands

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Abstract

A new dinuclear Ca(II) complex, {[Ca(bpy)(H2O)4]2(μ-1,5-NDS)}·(1,5-NDS) (1,5-NDS = 1,5-naphthalenedisulfonate bpy = 2,2′-bipyridine) has been successfully synthesized in water:ethanol (1:5) medium, and was characterized by elemental analysis, IR and thermal analysis. Structurally characterized with the aid of X-ray single-crystal diffraction analysis, which revealed that the complex crystallizes in the triclinic system with the P-1 space group, and the complex molecules exhibit a novel one-dimensional supramolecular chain structure via hydrogen bonding interactions. The antitumor activity of 1,5-naphthalenedisulfonic acid sodium ligand and the dinuclear Ca(II) complex against human hepatoma SMMC-7721 cell line and human lung adenocarcinoma A549 cell line reveals that the Ca(II) complex is more resistive to this cell line as compared to 1,5-naphthalenedisulfonic acid sodium ligand.

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Acknowledgments

The authors would like to thank the National Natural Science Foundation of China (Nos. 21171132 and 20671073), the Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (2010BSA07004) and Science Foundation of Weifang University.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Weifang University, Weifang, 261061, People’s Republic of China

    Xi-Shi Tai & Yan-Ping Zhang

  2. Department of Chemistry, Qinghai Normal University, Xining, 810008, People’s Republic of China

    Wen-Hua Zhao

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  1. Xi-Shi Tai
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  2. Yan-Ping Zhang
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Correspondence to Xi-Shi Tai.

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Tai, XS., Zhang, YP. & Zhao, WH. Synthesis, crystal structure and antitumor activity of a dinuclear calcium complex based on 1,5-naphthalenedisulfonate and 2,2′-bipyridine ligands. Res Chem Intermed 41, 4339–4347 (2015). https://doi.org/10.1007/s11164-014-1533-9

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