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Influence of Coffee Brew in Metabolic Syndrome and Type 2 Diabetes

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Abstract

This study aimed to evaluate the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats. Diabetic Zucker rats with metabolic syndrome and control Zucker rats were used for in vivo tests. The animals received daily doses of coffee drink by gavage for 30 days. After the treatment, the levels of glucose, triglycerides, total cholesterol and fractions, creatinine, uric acid, activity of aspartate aminotransferase and alanine aminotransferase were evaluated. Urea and creatinine levels were also analyzed in urine. By collaborating in the modulation of the metabolic syndrome and diabetes mellitus type 2, coffee drink helped in reducing serum glucose, total cholesterol and triglycerides. The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2.

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Abbreviations

CGA:

Chlorogenic acids

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

HDL-c:

High density lipoprotein–cholesterol

LDL-c:

Low density lipoprotein–cholesterol

VLDL-c:

Very low density lipoprotein–cholesterol

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Acknowledgments

We would like to thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq for the scholarship.

Conflict of interest

Sheila Andrade Abrahão has received research grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq. Rosemary Gualberto Fonseca Alvarenga Pereira, Raimundo Vicente de Sousa, Adriene Ribeiro Lima, Gabriela Previatti Crema and Bianca Barros declares that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed.

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Authors and Affiliations

  1. Fluminense Federal Institute, Av. Dario Vieira Borges, 235, 28360-000, Bom Jesus do Itabapoana, RJ, Brazil

    Sheila Andrade Abrahão

  2. Department of Food Science, Federal University of Lavras, Campus, 37200-000, Lavras, MG, Brazil

    Rosemary Gualberto Fonseca Alvarenga Pereira & Adriene Ribeiro Lima

  3. Department of Veterinary Medicine, Federal University of Lavras, Campus, 37200-000, Lavras, MG, Brazil

    Raimundo Vicente de Sousa, Gabriela Previatti Crema & Bianca Sacramento Barros

Authors
  1. Sheila Andrade Abrahão
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  2. Rosemary Gualberto Fonseca Alvarenga Pereira
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  3. Raimundo Vicente de Sousa
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  4. Adriene Ribeiro Lima
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  5. Gabriela Previatti Crema
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  6. Bianca Sacramento Barros
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Corresponding author

Correspondence to Sheila Andrade Abrahão.

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Abrahão, S.A., Pereira, R.G.F.A., de Sousa, R.V. et al. Influence of Coffee Brew in Metabolic Syndrome and Type 2 Diabetes. Plant Foods Hum Nutr 68, 184–189 (2013). https://doi.org/10.1007/s11130-013-0355-z

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  • DOI: https://doi.org/10.1007/s11130-013-0355-z

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