Abstract
Endoperoxides have received widespread interest as a research topic due to its ubiquitous structure, which confers interesting biological properties. It has been demonstrated that some endoperoxides possess antimalarial, cytotoxic, anti-inflammatory, neuroprotective, antiparasitic, antitumor, and antimicrobial activities. The present review summarizes the current knowledge about the structure, occurrence, peroxide detection methods, stability, biosynthesis, and biological activities of 206 endoperoxides isolated from 1911 to 2019, found in 115 plant species belonging to 36 different plant families. Thirty-five new endoperoxides of different plant species have been reported since the last published review. In order to simplify our analysis, we classified plant endoperoxides considering the nature of the secondary metabolite.
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Abbreviations
- 11β-HSD1:
-
11β-Hydroxysteroid dehydrogenase type 1
- CCID:
-
Circular chemo-repellent induced defect
- EC50 :
-
Maximal effective concentration 50%
- ED50 :
-
Effective dose 50%
- GI50 :
-
Growth inhibitory concentration 50%
- HBV:
-
Hepatitis B virus
- IC12 :
-
Inhibitory concentration that gives an inhibition zone of 12 mm
- l-NMMA:
-
N-methyl-l-arginine
- LPS:
-
Lipopolysaccharide
- MAP:
-
Mitogen-activated protein
- MIC:
-
Minimum inhibitory concentration
- MLC:
-
Minimum lethal concentration
- NGF:
-
Nerve growth factor
- PDE:
-
Phosphodiesterase
- PKA:
-
Protein kinase A
- ROS:
-
Reactive oxigen species
- SERT:
-
Serotonin transporter protein
- TPA:
-
12-O-Tetradecanoylphorbol-13-acetate
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Tamez-Fernández, J.F., Melchor-Martínez, E.M., Ibarra-Rivera, T.R. et al. Plant-derived endoperoxides: structure, occurrence, and bioactivity. Phytochem Rev 19, 827–864 (2020). https://doi.org/10.1007/s11101-020-09687-4
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DOI: https://doi.org/10.1007/s11101-020-09687-4