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An overview on genus garcinia: phytochemical and therapeutical aspects

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Abstract

The genus Garcinia belongs to the family Clusiaceae and has been involved in ayurvedic preparations to medicate various pathophysiological disorders. The bioactive molecules like hydroxycitric acid (HCA), flavonoids, terpenes, polysaccharides, procyanidines and polyisoprenylated benzophenone derivatives like garcinol, xanthochymol and guttiferone isoforms have been isolated from the genus Garcinia. The genus has received the attention of pharmaceutical industries due to their immense remedial qualities. The HCA has been known for its hypolipidemic property. The polyisoprenylated benzophenone and xanthone derivatives are known for their antioxidant, apoptotic, anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, anti-ulcer, anti-protozoal, and HAT inhibiting properties. Future studies on the synthesis of therapeutically important products and their analogs and evaluation of their safety and efficacy would be of great interest. Though the genus includes more than 300 species, we have made an effort to conceive the curative qualities of bioactive compounds of selected plants to the best of our knowledge.

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Abbreviations

HCA:

Hydroxy citric acid

HAT:

Histone acetylase transferase

MDA:

Malondialdehyde

STAT-1:

Signal transducer and activator of transcription-1

PMR:

Proton magnetic resonance

GK:

Garcinia kola

KV:

Kolaviron

GA:

Gambogic acid

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Acknowledgments

Authors thank Ministry of Human Resource Development (MHRD) and University Grant Commission (UGC), New Delhi, India, for recognizing University of Mysore as the Institute of Excellence and for the financial assistance.

Author information

Authors and Affiliations

  1. Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore, 570 006, India

    M. Hemshekhar, K. Sunitha, M. Sebastin Santhosh, K. Kemparaju, B. S. Vishwanath & K. S. Girish

  2. PG Department of Biochemistry, Tumkur University, Tumkur, India

    S. Devaraja

  3. Department of Biotechnology, University of Mysore, Manasagangothri, Mysore, 70006, India

    S. R. Niranjana

Authors
  1. M. Hemshekhar
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  2. K. Sunitha
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  3. M. Sebastin Santhosh
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  4. S. Devaraja
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  5. K. Kemparaju
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  6. B. S. Vishwanath
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  7. S. R. Niranjana
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  8. K. S. Girish
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Corresponding author

Correspondence to K. S. Girish.

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Hemshekhar, M., Sunitha, K., Santhosh, M.S. et al. An overview on genus garcinia: phytochemical and therapeutical aspects. Phytochem Rev 10, 325–351 (2011). https://doi.org/10.1007/s11101-011-9207-3

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  • DOI: https://doi.org/10.1007/s11101-011-9207-3

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