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Evidence of Selective Interaction of Nerve Growth Factor Dipeptide Mimetic GK-2 with TrkA Receptor Using TrkA and TrkB Knockout HT-22 Cells

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Pharmaceutical Chemistry Journal Aims and scope

TrkA and TrkB knockout HT-22 cell lines were used to prove that the neuroprotective properties of GK-2 [bis(N-monosuccinyl-L-glutamyl-L-lysine hexamethylenediamide], a low-molecular-weight dipeptide mimetic of the NGF 4th loop, are definitely mediated by selective interaction with TrkA receptor upon oxidative stress-induced cellular damage in vitro.

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References

  1. L. Aloe, M. Rocco, B. Balzamino, et al., Curr. Neuropharmacol., 13(3), 294 – 303 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. J. M. Conner, K. M. Franks, A. K. Titterness, et al., J. Neurosci., 29(35), 10883 – 10889 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. S. M. Morillo, E. P. Abanto, and M. J. Roman, Mol. Cell. Biol., 32(14), 2722 – 2737 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. L. F. Reichardt, Philos. Trans. R. Soc., B, 361(1473), 1545 – 1564 (2006).

  5. J. Cai, F. Hua, L. Yuanet, et al., BioMed Res. Int., Art. ID 601084 (2014).

  6. S. Do Carmo, B. Kannel, and A. C. Cuello, Cells, 11(1), 16 (2021); doi: https://doi.org/10.3390/CELLS11010016.

  7. L. L. Pedre, N. P. Fuentes, L. A. Gonzalez, A. McRae, et al., Brain Res., 952, 122 – 127 (2002).

    Article  Google Scholar 

  8. X. Luan, H. Qiu, X. Hong, et al., Clin. Chim. Acta, 488, 20 – 24 (2019).

    Article  CAS  PubMed  Google Scholar 

  9. J. Houtz, P. Borden, and A. Ceasrine, Dev. Cell, 39(3), 329 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. M. L. Rocco, M. Soligo, and L. Manni, Curr. Neuropharmacol., 16(10), 1455 – 1465 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. S. Maliartchouk, Y. Feng, L. Ivanisevic, et al., Mol. Pharmacol., 57, 385 – 391 (2000).

    CAS  PubMed  Google Scholar 

  12. L. LeSauteur, S. Maliartchouk, and H. Le Jeune, J. Neurosci., 16(4), 1308 – 1316 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. M. A. Bruno, J. Neurosci., 24(37), 8009 – 8018 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. P. Jain, R. Li, and T. Lama, Exp. Eye Res., 93(4), 503 – 512 (2011).

    Article  CAS  PubMed  Google Scholar 

  15. D. Scarpi, D. Cirelli, C. Matrone, et al., Cell Death Dis., 3(7), e339 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. T. A. Gudasheva, P. Y. Povarnina, T. A. Antipova, et al., J. Biomed. Sci., 22(5), 106 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  17. T. A. Gudasheva, T. A. Antipova, and S. B. Seredenin, Dokl. Akad. Nauk, 434(4), 549 – 552 (2010).

    Google Scholar 

  18. T. A. Gudasheva, I. O. Logvinov, S. V. Nikolaev, et al., Dokl. Ross. Akad. Nauk, Nauki Zhizni, 494(1), 486 – 490 (2020).

  19. P. Yu. Povarnina, O. I. Vorontsova, T. A. Gudasheva, et al., Byull. Eksp. Biol. Med., 5(3), 88 – 95 (2013).

    Google Scholar 

  20. P. Yu. Povarnina, O. N. Vorontsova, T. A. Guadsheva, et al., Acta Nat., 5(3) (48), 88 – 95 (2013).

  21. Yu. V. Zarzhetskii, M. Sh. Avrushchenko, V. V. Moroz, et al., Byull. Eksp. Biol. Med., 159(4), 442 – 445 (2015).

    Article  Google Scholar 

  22. S. B. Seredenin, P. Yu. Povarnina, and T. A. Guadsheva, Zh. Nevrol. Psikhiatr. im. S. S. Korsakova, 7, 49 – 53 (2018).

    Article  Google Scholar 

  23. T. A. Gudasheva, P. Yu. Povarnina, A. A. Volkova, et al., Acta Nat., 2(41), 37 – 43 (2019).

    Google Scholar 

  24. A. V. Sorokina, S. V. Alekseeva, I. A. Miroshkina, et al., Farmakokinet. Farmakodin., 2, 51 – 58 (2019).

    Google Scholar 

  25. F. A. Ran, P. D. Hsu, and J. Wright, Nat. Protoc., 8(11), 2281 – 2308 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. G. R. Jackson, K. Werrbach-Perez, E. L. Ezell, et al., Brain Res., 592(1) – 2, 239 – 248 (1992).

  27. Y. Ueda, E. Walsh, and H. Nakanishi, Neurosci. Lett., 165(1) – 2, 203 – 207 (1994).

  28. J. B. Davis and P. Maher, Brain Res., 652(1), 169 – 173 (1994).

    Article  CAS  PubMed  Google Scholar 

  29. B. H. Morimoto and D. E. Koshland, Neuron, 5(6), 875 – 880 (1990).

    Article  CAS  PubMed  Google Scholar 

  30. P. Wu, X. Shi, M. Luo, et al., Amino Acids, 52(1), 87 – 102 (2020).

    Article  CAS  PubMed  Google Scholar 

  31. S. Shim and J. Kwon, Food Chem. Toxicol., 50. No. 5, 1454 – 1459 (2012).

    Article  CAS  PubMed  Google Scholar 

  32. H. Liu, J. Wang, R. Yan, et al., Histol. Histopathol., 35(11), 1353 – 1361 (2020).

    CAS  PubMed  Google Scholar 

  33. I. Kanazawa, Trends Mol. Med., 7(8), 339 – 344 (2001).

    Article  CAS  PubMed  Google Scholar 

  34. J. C. Conover and G. D. Yancopoulos, Rev. Neurosci., 8(1), 13 – 27 (1997).

    Article  CAS  PubMed  Google Scholar 

  35. Z. H. Wang, J. Xiang, X. Liu, et al., Cell Rep., 28(3), 655 – 669 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

The work was supported by the Russian Science Foundation (Project No. 18-15-00381).

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Authors and Affiliations

  1. Research Zakusov Institute of Pharmacology, 8 Baltiiskaya ST., Moscow, 125315, Russia

    T. A. Antipova, T. A. Gudasheva, S. V. Nikolaev, I. O. Logvinov, O. V. Serova, A. A. Gavrilenkova, P. Yu. Povarnina, A. V. Tarasiuk, Yu. V. Vakhitova & S. B. Seredenin

  2. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya ST., Moscow, 117997, Russia

    I. E. Deev

Authors
  1. T. A. Antipova
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  2. I. E. Deev
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Corresponding author

Correspondence to T. A. Gudasheva.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 12, pp. 18 – 22, December, 2022.

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Antipova, T.A., Deev, I.E., Gudasheva, T.A. et al. Evidence of Selective Interaction of Nerve Growth Factor Dipeptide Mimetic GK-2 with TrkA Receptor Using TrkA and TrkB Knockout HT-22 Cells. Pharm Chem J 56, 1568–1572 (2023). https://doi.org/10.1007/s11094-023-02828-x

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