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Role of Dopaminergic Mechanisms in the Formation of Stress-Induced Ulcer Damages to the Duodenum and Stomach in Rats

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Neurophysiology Aims and scope

Intraperitoneal injections of 2.5 mg/kg reserpine daily for 3 days combined with immobilization/pain stress evoked the development of ulcerous damages to the duodenum and stomach in rats. This is accompanied by increases in the content of malonic dialdehyde (MDA) and activity of superoxide dismutase (SOD) in erythrocytes, level of vitamin C in the blood plasma, and activity of SOD in a homogenate of the duodenum tissue. Injections of 0.5 mg/kg L-deprenyl (i.p.) and 50 mg/kg pentoxifylline (i.p.) provided protection effects with respect to stress-induced ulcers; the influences of these agents were mutually potentiated.

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  1. Odessa National Medical University, Ministry of Public Health of Ukraine, Odessa, Ukraine

    I. S. Antonyan & L. S. Godlevskii

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  1. I. S. Antonyan
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  2. L. S. Godlevskii
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Correspondence to I. S. Antonyan.

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Antonyan, I.S., Godlevskii, L.S. Role of Dopaminergic Mechanisms in the Formation of Stress-Induced Ulcer Damages to the Duodenum and Stomach in Rats. Neurophysiology 44, 79–82 (2012). https://doi.org/10.1007/s11062-012-9271-3

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  • DOI: https://doi.org/10.1007/s11062-012-9271-3

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