Skip to main content
SpringerLink
Log in

Polysomy of chromosomes 1 and 19: an underestimated prognostic factor in oligodendroglial tumors

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

The clinical significance of chromosomes 1 and 19 deletion was well established in oligodendroglial tumors (ODGs). This study was designed to evaluate the prognostic implication of chromosomes 1 and 19 polysomy in gliomas. 584 patients with histological diagnosis of primary gliomas enrolled in the study. Chromosomes 1 and 19 status was detected with fluorescence in situ hybridization (FISH). Of the 584 cases, the frequency of 1q and 19p polysomy in mixed gliomas was significantly higher than ODGs or astrocytic tumors (1q P = 0.032 and P = 0.044; 19p P = 0.024 and P = 0.027); the frequency of 1q and 19p polysomy in low-grade gliomas (WHO II) was relatively lower compared with WHO III or WHO IV (1q P = 0.097 and P = 0.026; 19p P = 0.04 and P = 0.002). 1q, 19p and co-polysomy were confirmed as risk factors conveyed unfavorable outcomes, which has been further validated in both anaplastic oligodendroglial tumors (AOGs) (P = 0.07, P = 0.028 and P = 0.054 for PFS; P = 0.007, P = 0.001 and P = 0.002 for OS, respectively) and glioblastomas with oligodendroglioma component (GBMOs) (P = 0.005, P < 0.001 and P < 0.001 for PFS; P = 0.136, P = 0.006 and P = 0.051 for OS, respectively). Based on chromosomes 1/19 co-deletion and co-polysomy, AOGs and GBMOs could be divided into three subgroups which harbored distinct prognosis (AOGs P < 0.001 for PFS and P < 0.001 for OS; GBMOs P < 0.001 for PFS and P = 0.012 for OS). Chromosomes 1/19 polysomy are potential prognostic factors which confer unfavorable outcomes. The molecular prognostic grouping model based on chromosomes 1/19 co-polysomy and co-deletion better predicts prognosis and provides a more reliable information for treatment decision-making.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Schwartzbaum JA, Fisher JL, Aldape KD et al (2006) Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol 2(494–503):1–516

    Google Scholar 

  2. Omuro A, DeAngelis LM (2013) Glioblastoma and other malignant gliomas: a clinical review. JAMA 310:1842–1850

    Article  PubMed  CAS  Google Scholar 

  3. Jenkins RB, Blair H, Ballman KV et al (2006) A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma. Cancer Res 66:9852–9861

    Article  PubMed  CAS  Google Scholar 

  4. Cairncross G, Berkey B, Shaw E et al (2006) Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. J Clin Oncol 24:2707–2714

    Article  PubMed  CAS  Google Scholar 

  5. Louis DN, Ohgaki H, Wiestler OD et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ambros PF, Ambros IM (2001) Pathology and biology guidelines for resectable and unresectable neuroblastic tumors and bone marrow examination guidelines. Med Pediatr Oncol 37:492–504

    Article  PubMed  CAS  Google Scholar 

  7. Snuderl M, Eichler AF, Ligon KL et al (2009) Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss. Clin Cancer Res 15:6430–6437

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  8. Kaloshi G, Benouaich-Amiel A, Diakite F et al (2007) Temozolomide for low-grade gliomas: predictive impact of 1p/19q loss on response and outcome. Neurology 68:1831–1836

    Article  PubMed  CAS  Google Scholar 

  9. Kujas M, Lejeune J, Benouaich-Amiel A et al (2005) Chromosome 1p loss: a favorable prognostic factor in low-grade gliomas. Ann Neurol 58:322–326

    Article  PubMed  CAS  Google Scholar 

  10. Hoang-Xuan K, Capelle L, Kujas M et al (2004) Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. J Clin Oncol 22:3133–3138

    Article  PubMed  CAS  Google Scholar 

  11. van den Bent MJ, Carpentier AF, Brandes AA et al (2006) Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. J Clin Oncol 24:2715–2722

    Article  PubMed  Google Scholar 

  12. Cairncross JG, Ueki K, Zlatescu MC et al (1998) Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 90:1473–1479

    Article  PubMed  CAS  Google Scholar 

  13. Jansen M, Yip S, Louis DN (2010) Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers. Lancet Neurol 9:717–726

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  14. Wiens AL, Cheng L, Bertsch EC et al (2012) Polysomy of chromosomes 1 and/or 19 is common and associated with less favorable clinical outcome in oligodendrogliomas: fluorescent in situ hybridization analysis of 84 consecutive cases. J Neuropathol Exp Neurol 71:618–624

    Article  PubMed  CAS  Google Scholar 

  15. Ren X, Jiang H, Cui X et al (2013) Co-polysomy of chromosome 1q and 19p predicts worse prognosis in 1p/19q codeleted oligodendroglial tumors: FISH analysis of 148 consecutive cases. Neuro Oncol 15:1244–1250

    Article  PubMed  PubMed Central  Google Scholar 

  16. Heegaard S, Sommer HM, Broholm H et al (1995) Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis. Cancer 76:1809–1813

    Article  PubMed  CAS  Google Scholar 

  17. Kros JM, Hop WC, Godschalk JJ et al (1996) Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas. Cancer 78:1107–1113

    Article  PubMed  CAS  Google Scholar 

  18. Hagel C, Krog B, Laas R et al (1999) Prognostic relevance of TP53 mutations, p53 protein, Ki-67 index and conventional histological grading in oligodendrogliomas. J Exp Clin Cancer Res 18:305–309

    PubMed  CAS  Google Scholar 

  19. Theeler BJ, Yung WK, Fuller GN et al (2012) Moving toward molecular classification of diffuse gliomas in adults. Neurology 79:1917–1926

    Article  PubMed  CAS  PubMed Central  Google Scholar 

Download references

Acknowledgments

We acknowledge financial support by Beijing Natural Science Foundation (7122061).

Conflict of interest

No potential conflict of interest were disclosed.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders and Beijing Key Laboratory of Brain Tumor, Beijing, 100050, People’s Republic of China

    Haihui Jiang, Xiaohui Ren, Zhe Zhang, Wei Zeng & Song Lin

  2. Department of Pathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, People’s Republic of China

    Junmei Wang

Authors
  1. Haihui Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaohui Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhe Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wei Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Junmei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Song Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Song Lin.

Electronic supplementary material

Below is the link to the electronic supplementary material.

11060_2014_1526_MOESM1_ESM.tif

Fig. S1 Glioma with 1q (green) polysomy and 1p (red) deletion (a), 19p (green) polysomy and 19q (red) deletion (b). Glioma with 1q (green) diploidy and 1p (red) deletion (c), 19p (green) diploidy and 19q (red) deletion (d)

11060_2014_1526_MOESM2_ESM.tif

Fig. S2 Univariate analyses documented that 1q, 19p and both polysomy were associated with the decreased PFS and OS of patients with AOGs (P = 0.007, P = 0.028 and P = 0.054 for PFS; P = 0.007, P = 0.001 and P = 0.002 for OS, respectively)

11060_2014_1526_MOESM3_ESM.tif

Fig. S3 Univariate analyses documented that 1p, 19q and both deletion were associated with the prolonged PFS and OS of patients with AOGs (P = 0.001, P < 0.001 and P < 0.001 for PFS; P = 0.031, P = 0.017 and P = 0.014 for OS, respectively)

11060_2014_1526_MOESM4_ESM.tif

Fig. S4 Univariate analyses documented that 1q, 19p and both polysomy were associated with the decreased PFS and OS of patients with GBMOs (P = 0.005, P < 0.001 and P < 0.001 for PFS; P = 0.136, P = 0.006 and P = 0.051 for OS, respectively)

11060_2014_1526_MOESM5_ESM.tif

Fig. S5 Univariate analyses documented that 1p, 19q and both deletion were associated with the prolonged PFS and OS of patients with GBMOs (P = 0.005, P = 0.049 and P = 0.009 for PFS; P = 0.011, P = 0.034 and P = 0.015 for OS, respectively)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jiang, H., Ren, X., Zhang, Z. et al. Polysomy of chromosomes 1 and 19: an underestimated prognostic factor in oligodendroglial tumors. J Neurooncol 120, 131–138 (2014). https://doi.org/10.1007/s11060-014-1526-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-014-1526-y

Keywords

Search

Navigation