Abstract
This study was designed to find whether long-term survivors (LTSs) exhibit molecular genetic differences compared with short-term survivors (STSs) in patients with GBM. Tumors from 12 patients initially diagnosed with GBM and survived longer than 36 months (LTSs) were compared with 30 patients with GBM and STSs (survival <18 months) for detecting of MGMT promoter methylation, 1p/19q LOH and IDH1 mutation. IDH1 mutation and MGMT promoter methylation were significantly more frequent in the LTSs group (P = 0.039 and 0.017, respectively). The incidence of 1p/19q co-deletion was not significantly different (P = 1.0). IDH1 mutation and MGMT promoter methylation might be independent, significant, and favorable factors for LTSs with GBM.
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Acknowledgments
This study was supported by Beijing Natural Science Foundation (7122061). The author appreciate Dr. Lin Luo and Dr. Jun-Mei Wang for pathology diagnosis of GBM, the Pathology Department, Beijing Neurosurgical Institute. Dr. Guang Li, Pathology Department, Beijing Tiantan Hospital, Capital Medical University.
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No potential conflicts of interest were disclosed.
Funding
Beijing Natural Science Foundation (7122061).
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Guo-Bin Zhang and Xiang-Li Cui are contributed equally to this study.
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Zhang, GB., Cui, XL., Sui, DL. et al. Differential molecular genetic analysis in glioblastoma multiforme of long- and short-term survivors: a clinical study in Chinese patients. J Neurooncol 113, 251–258 (2013). https://doi.org/10.1007/s11060-013-1102-x
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DOI: https://doi.org/10.1007/s11060-013-1102-x