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Primary brain tumour epidemiology in Georgia: first-year results of a population-based study

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Abstract

A population-based cohort study was initiated in Georgia in March 2009 to collect epidemiologic data of malignant and non-malignant primary brain tumours. During the first year, 473 incident cases were identified. For a population of 4.3 million, the annual incidence rate was 10.25 per 100,000 inhabitants, age-standardized to the year 2000 US population. Non-malignant tumours constituted about 66 % of all tumours. Males accounted for 40 % and females for 60 % of the cases. Crude incidence rates by histology were highest for meningiomas (2.92/100,000), pituitary adenoma (1.16/100,000) and glioblastomas (0.64/100,000), which was in agreement with the frequency of reported histology: meningiomas—45.2 %, pituitary adenoma—18.0 % and glioblastomas—9.9 %. The age-standardized incidence rates were higher among females than males for all primary brain tumours (11.05 vs. 8.44/100,000) as well as for individual histologies except for glioblastoma and several other neuroepithelial tumours. Some differences compared with 2004–2005 Central Brain Tumor Registry of the United States data may be explained by a higher percentage of unclassified tumours (37 %) in our study. We suggest further studies to clarify the nature of this discrepancy.

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Acknowledgments

The authors thank Dr.Tatiana Mermanishvili (Head, Department of Neuropathology, City Hospital N5, Tbilisi, Georgia) for her valuable support in reviewing brain tumour cases in histopathology database. This work was supported by Grant from Shota Rustaveli National Science Foundation (GNSF/ST08/6-463). The funding organisation had no role in the design, conduct or analysis of this study, or in the preparation of this report. Contributors: DG: study conception and design, designing data collection tools, data collection monitoring, statistics, cleaning and analysing the data, writing and critical revision of the paper. NS, GS: data acquisition, cleaning and analysing the data. SR: study design, statistics, revision of the draft paper. AT and RS: study conception and design and revision of the draft paper.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

Ethical approval was obtained from the Tbilisi State University Medical Faculty ethics committee.

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Authors and Affiliations

  1. Department of Neurology & Neurosurgery, Faculty of Medicine, Tbilisi State University, Tbilisi, 0112, Georgia

    David Gigineishvili, Nino Shengelia, Giorgi Shalashvili, Alexander Tsiskaridze & Roman Shakarishvili

  2. Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, 8001, Zurich, Switzerland

    Sabine Rohrmann

  3. Sarajishvili Institute of Neurology, Tevdore Mgvdlis str. 13, Tbilisi, 0112, Georgia

    David Gigineishvili

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  1. David Gigineishvili
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  2. Nino Shengelia
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  3. Giorgi Shalashvili
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  4. Sabine Rohrmann
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  5. Alexander Tsiskaridze
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  6. Roman Shakarishvili
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Correspondence to David Gigineishvili.

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Gigineishvili, D., Shengelia, N., Shalashvili, G. et al. Primary brain tumour epidemiology in Georgia: first-year results of a population-based study. J Neurooncol 112, 241–246 (2013). https://doi.org/10.1007/s11060-013-1054-1

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  • DOI: https://doi.org/10.1007/s11060-013-1054-1

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