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Synthesis and pharmacological properties of polysubstituted 2-amino-4H-pyran-3-carbonitrile derivatives

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Abstract

2-Amino-3-cyano-4H-chromenes are structural core motifs that received increasing attention in the last years due to their interesting potential pharmacological properties. In this review, the synthetic methods for these compounds are classified based on the type of catalyst in the pertinent reactions. In addition, the wide range of pharmacological properties of these compounds is covered in a separate section.

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Acknowledgements

This research was supported by a grant from Iran National Science Foundation (INSF).

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Authors and Affiliations

  1. Department of Chemistry, University of Guilan, PO Box 41335-1914, Rasht, Iran

    Zahra Tashrifi

  2. Faculty of Fouman, College of Engineering, University of Tehran, Fuman, Iran

    Mohammad Mohammadi-Khanaposhtani

  3. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran

    Haleh Hamedifar & Samira Ansari

  4. CinnaGen Research and Production Co, Karaj, Alborz, Iran

    Haleh Hamedifar & Samira Ansari

  5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Bagher Larijani & Mohammad Mahdavi

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  1. Zahra Tashrifi
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Tashrifi, Z., Mohammadi-Khanaposhtani, M., Hamedifar, H. et al. Synthesis and pharmacological properties of polysubstituted 2-amino-4H-pyran-3-carbonitrile derivatives. Mol Divers 24, 1385–1431 (2020). https://doi.org/10.1007/s11030-019-09994-9

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