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Expression of inducible nitric oxide synthase in human cutaneous leishmaniasis

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Abstract

Cutaneous leishmaniasis (CL) is an infectious disease caused by Leishmania parasite. The expression of inducible nitric oxide synthase (iNOS) and generation of nitric oxide in response to IFN-γ and TNF-α is important in control of infection. The aim of the study was to determine the expression of iNOS in the lesions of Leishmania tropica, and whether there was a correlation between the level of expression and the duration of the disease. Punch biopsy was performed from patients (n = 29) and iNOS immunohistochemical staining was applied. Expression of iNOS protein was detected 82.8% of patients. There was a strong expression with the duration of the disease less than 6 months (p < 0.002). These findings demonstrate that iNOS has a role in L. tropica especially during the early stages of the infection. (Mol Cell Biochem xxx: 147–149, 2005)

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Authors and Affiliations

  1. Department of Dermatology, Mustafa Kemal University, Faculty of Medicine, 31100, Hatay, Turkey

    Gamze Serarslan

  2. Department of Pathology, Mustafa Kemal University, Faculty of Medicine, 31100, Hatay, Turkey

    Esin Atik

  3. Akevler Mah. 6/1 Sok. Melis Apt., C Bl 5/12, 31100, Antakya/Hatay, Turkey

    Gamze Serarslan

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  1. Gamze Serarslan
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  2. Esin Atik
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Correspondence to Gamze Serarslan.

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Serarslan, G., Atik, E. Expression of inducible nitric oxide synthase in human cutaneous leishmaniasis. Mol Cell Biochem 280, 147–149 (2005). https://doi.org/10.1007/s11010-005-8542-3

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  • DOI: https://doi.org/10.1007/s11010-005-8542-3

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